Salifying preparation process of ibuprofen arginine

Abstract

The invention provides a salifying preparation process of ibuprofen arginine. A mode of firstly adding water is adopted, high temperature heating is performed to adjust the feeding sequence and the interval time of adding the ibuprofen and the arginine, the specific heating temperature and heating time are set, and vacuum drying is performed after mixing and stirring. The problems encountered by material transfer can be reduced while it is guaranteed that qualified and uniform samples are obtained; meanwhile, residual temperature vacuum drying is performed in situ, the drying time is shorter and the safety is also guaranteed.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to a preparation process for arginine ibuprofen salt formation. Background technique [0002] Ibuprofen (Ibuprofen, 1) is one of the non-steroidal anti-inflammatory drugs (NSAID). The drug inhibits cyclooxygenase and reduces the synthesis of prostaglandins to produce analgesic and anti-inflammatory effects, and has an antipyretic effect through the hypothalamic thermoregulatory center. It is widely used for its anti-inflammatory, antipyretic and analgesic effects, less adverse reactions, and easy absorption after oral administration, especially in the treatment or adjuvant treatment of various pediatric diseases. At present, there are many dosage forms of ibuprofen on the market at home and abroad, including ordinary tablets, sustained-release tablets, capsules, suspensions, suppositories, creams, gels, etc., which are widely used clinically. [0003] Ibuprofen arginine salt, al...

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Problems solved by technology

[0004] At present, the salt-forming process of preparing ibuprofen and arginine generally uses organic solvents for reaction, which not only has the problem of inflammability and explosion, but also is not conducive to patient safety; while adding ibuprofen and arginine first, and then The method of adding water has slow heat transfer, long reaction time, and sometimes it is difficult to start the reaction; the temperature of the sample in the salt-forming reaction can reach 110-120°C, and the temperature is relatively high. If the transfer process is added, it is necessary to consider transferring the sample after cooling down, which takes a long time. Direct transfers need to consider personnel safety issues

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