A kind of biomedical material and preparation method thereof
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A technology of biomedical and metal materials, applied in the field of biomedical materials and their preparation, can solve problems such as implant corrosion, tissue influence, implant bacterial infection, etc., and achieve improved corrosion resistance, enhanced antibacterial, and good combination Effect
Active Publication Date: 2020-11-20
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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[0006] Purpose of the invention: The currently used biomedical titanium alloy does not have antibacterial ability, which is easy to cause bacteria to adhere and multiply on the surface of the implant, so as to form a biofilm, which leads to bacterial infection of the implant, and corrosion of the implant during service Cause self-degeneration, the formed corrosion products may seriously affect the surrounding normal tissues. The present invention provides a biomedical material by means of double-glow plasma surface alloying technology. Corrosion-resistant and antibacterial coatings are prepared on the surface, which can be adapted to metal implant materials of any shape and size
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Embodiment 1
[0034] Embodiment 1: the preparation of biomedical metal material
[0035] (1) Grind and polish the surface of a bulk Ti-45Nb alloy sample with a size of 10mm×10mm×3mm to 1200#, then ultrasonically clean it with a cleaning agent prepared by ethanol and acetone with a volume ratio of 4:1, and then dry it ;
[0036] (2) Put the processed Ti-45Nb alloy sample and Zr-Ag alloy target into the double-glow plasma surface metallurgy metal infiltration furnace. The Zr content in the Zr-Ag alloy target is 80% by mass percentage, and the Ag The content is 20%, the Ti-45Nb alloy sample is used as the workpiece electrode, the Zr-Ag alloy target is used as the source electrode, and the distance between the two electrodes is adjusted to 20mm;
[0037] (3) Turn on the mechanical pump, then open the exhaust valve, evacuate to below 0.2Pa, ensure the vacuum in the furnace, and close the exhaust valve;
[0038] (4) Turn on the argon gas bottle, open the argon gas valve, and then turn on the fl...
Embodiment 2
[0049] Embodiment 2: the preparation of biomedical metal material
[0050] (1) Grind and polish the surface of a bulk Ti-45Nb alloy sample with a size of 10mm×10mm×3mm to 1200#, then ultrasonically clean it with a cleaning agent prepared by ethanol and acetone with a volume ratio of 4:1, and then dry it ;
[0051] (2) Put the treated Ti-45Nb alloy sample and Zr-Ag mixed grid-shaped target into the double-glow plasma surface metallurgy metal infiltration furnace. The Zr target is high-purity zirconium (purity above 99.95%), and the Ag target is It is high-purity silver (purity above 99.99%), and it is connected by pure zirconium rods arranged at intervals. The Zr content in the Zr-Ag alloy target is calculated as 50% by mass percentage, and the Ag content is 50%. The Ti-45Nb alloy sample is used as For the workpiece pole, the Zr-Ag mixed grid target is used as the source pole, and the distance between the two poles is adjusted to 25mm;
[0052] (3) Turn on the mechanical pump...
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Abstract
The invention discloses a biomedical material and a preparation method thereof. The metal material comprises a matrix composed of titanium-niobium-based alloy and an alloy coating located on the surface of the matrix. The alloy coating is composed of a deposition layer in the thickness ranging from 5 micrometers to 10 micrometers and a diffusion layer with in thickness ranging from 5 micrometers to 8 micrometers, the diffusion layer is located between the deposition layer and the matrix, the diffusion layer is formed by diffusion of Zr-Ag alloy and titanium-niobium-based alloy, the contents ofZr and Ag are reduced in a gradient manner from the surface layer to the bottom layer of the diffusion layer, and the contents of Ti and Nb are increased in a gradient manner. In the diffusion layer,an alloy phase containing the element Zr can be formed due to mutual diffusion of elements, so that the corrosion resistance of the matrix can be remarkably improved; the antibacterial effect of thesurface of the alloy coating is enhanced through the release of silver ions and the synergistic effect of Zr and Ag; due to the potential difference between Zr and Ag, the formed micro-current can also play an antibacterial role, the application range of the biomedical titanium alloy is expanded, the service life of the biomedical titanium alloy is prolonged, and the purpose of long-term service in the human body is achieved.
Description
technical field [0001] The invention relates to a biomedical material and a preparation method thereof, in particular to a biomedical material and a preparation method thereof. Background technique [0002] Due to its excellent comprehensive mechanical properties and biocompatibility, titanium alloys are widely used in biomedical metal implants to replace damaged human bones and joints. Among them, β-type titanium alloys composed entirely of non-toxic elements (Titanium-niobium-based alloy), as a new generation of bone tissue replacement material, has attracted the close attention of material workers at home and abroad. Because it needs to serve in the human body for a long time, the service life even needs to reach 15 to 20 years, and the working environment in the human body is very complicated, in which the bacteria that grow in the human body adhere and multiply on the surface of the implant, so as to form a biofilm and cause implantation. Bacterial infection of implant...
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