Glomerular disease classification and typing model based on immunoglobulin quantitative detection and application thereof

A glomerular disease, immunoglobulin technology, applied in the field of biomedicine, can solve the problem of single detection method of glomerular disease

Pending Publication Date: 2020-04-07
SHENGJING HOSPITAL OF CHINA MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, in the prior art, the classification and typing of patients with glomerular diseases is still relatively simple, and the corresponding detection methods for glomerular diseases are also relatively simple. Therefore, it is urgent to establish a classification and typing model for common clinical glomerular diseases. Predict the type of renal disease in patients, and provide reference for further research on the pathogenesis and clinical diagnosis and treatment of different glomerular diseases

Method used

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  • Glomerular disease classification and typing model based on immunoglobulin quantitative detection and application thereof
  • Glomerular disease classification and typing model based on immunoglobulin quantitative detection and application thereof
  • Glomerular disease classification and typing model based on immunoglobulin quantitative detection and application thereof

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Embodiment 1

[0079] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments. What has been described is by way of explanation, not limitation, of the invention.

[0080] 1. Sample collection

[0081] The samples were from Shengjing Hospital Affiliated to China Medical University, and were diagnosed as IgA nephropathy (IgA nephropathy, IgAN), membranous nephropathy (Membranous nephropathy, IMN), minimal change disease (minimal change disease, MCN) and lupus nephropathy through collection of kidney tissue biopsy or clinical symptoms Nephritis (Lupus nephritis, LN), diabetic nephropathy (Diabetic Nephrothy, DN), allergic purpura nephritis (Henoch- Purpuraglomerulonephritis (HSPN) tissue samples were 50 cases each, focal segmental glomerulosclerosis (focal segmental glomerulosclerosis, FSGS) tissue samples were 44 cases, and ANCA-associated systemic vasculitis glomerulonephritis (AASVG) tissue samples were 25 cases . 50 ...

Embodiment 2

[0100] Adopt the method for embodiment 1 to measure the immunoglobulin concentration of certain patient's serum, measured value is as table 1:

[0101] Table 1

[0102] Types of Immunoglobulins IgA_2 IgA1_2 IgA2_2 IgG_2 IgG1_2 IgG2_2 IgG3 IgG4_2 Concentration value (g / L) 1.63 5.35 0.06 14.57 2.76 0.10 0.076 0.013

[0103] Substitute the above immunoglobulin concentration values ​​into the multivariate normal distribution model of the immunoglobulin group to obtain the probability of each glomerular disease. The probability values ​​are shown in Table 2:

[0104] Table 2

[0105] disease category IgAN IMN MCN FSGS LN PN DN ANCA probability value 1.54E-07 0.007790888 0.00029248 0.00043365 1.97765E-05 4.46247E-06 3.75918E-07 2.3761E-06

[0106] Comparing each probability value shows that the patient suffers from idiopathic membranous nephropathy (IMN).

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Abstract

The invention provides an establishment method of a glomerular disease classification and typing model based on immunoglobulin quantitative detection and an application thereof in detection and classification and typing of glomerular diseases. The model can classify and classify patients with glomerular diseases so as to support clinical decisions, reduce medical expenditure, reduce infection probability and improve patient acceptability.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a method for detecting and classifying glomerular diseases based on quantitative detection of immunoglobulin. Background technique [0002] Chronic kidney disease (chronic kidney disease, CKD) is one of the major diseases threatening the world's public health. In my country, the incidence of CKD has reached 13%, and the incidence is still increasing in recent years. Epidemiological survey based on renal biopsy shows that glomerular disease (GD) plays a major role in CKD in my country, mainly including primary glomerulopathy (PG) and secondary glomerular disease (secondaryglomerulopathy, SG), of which PG accounts for about 80%, the vast majority. These patients usually have similar clinical manifestations and histopathological features, but the treatment methods of each disease are quite different, and the individual response to treatment, disease progression and prognosis a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/30G16H50/20G06K9/62G01N33/68
CPCG16H50/20G16H50/30G01N33/6893G01N2800/347G06F18/24G06F18/214
Inventor 于晓波秦晓松刘建华李阳
Owner SHENGJING HOSPITAL OF CHINA MEDICAL UNIV
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