Polymyxin E liposome as well as preparation method and application thereof

Abstract

The invention relates to a polymyxin E liposome. The polymyxin E liposome comprises the following components: polymyxin E sulfate, first-class phospholipid, second-class phospholipid, cholesterol, anantioxidant, an excipient and a buffer agent. Different from other phospholipid complex products, the polymyxin E liposome provided by the invention has the following advantages: the microstructure ofthe polymyxin E liposome is that a drug is embedded into a phospholipid bilayer of the liposome and the drug and phospholipid are not simply compounded, so the polymyxin E liposome has better structural stability, slow release property and a longer half-life period.

Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and in particular relates to a polymyxin E liposome and a preparation method and application thereof. Background technique

[0002] Polymyxin E is a group of polypeptide antibiotics produced by Bacillus polymyxa. Its sulfate salt is commonly used. It is a white crystalline powder, easily soluble in water, hygroscopic, stable in acidic solution, and its neutral solution is at room temperature. Standing for a week does not affect the potency, and the alkaline solution is unstable. It has antibacterial effect on Gram-negative bacteria such as Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Haemophilus, Enterobacter, Salmonella, Shigella, pertussis, Pasteurella and Vibrio. Proteus, Neisseria, Serratia, Providencia, Gram-negative bacteria and obligate anaerobic bacteria are not sensitive to this class of drugs. Bacteria have cross-resistance to this product and polymyxin E, but ...