Biomarkers, screening methods and uses of osteopeptide intervention in the treatment of osteoporosis

Abstract

The invention discloses biomarkers in osteopeptide intervention treatment of osteoporosis, including lipids and lipid molecules, organic acids and their derivatives and / or neurotransmitter substances, and lipids and lipid molecules are the following substances Any one or several: taurine, arachidonic acid, 1‑palmitoyl‑2‑hydroxy‑sn‑glycerol‑3‑phosphoethanolamine, (4Z,7Z,10Z,13Z,16Z,19Z)‑4, 7,10,13,16,19‑docosahexaenoic acid, 1‑stearyl‑2‑hydroxy‑sn‑glycero‑3‑phosphocholine, taurodeoxycholic acid, taurodeoxychole acid and taurocholate. The invention discloses a screening method for osteopeptide anti-osteoporosis biomarkers. The invention discloses the use of biomarkers. The invention provides a demonstration study for the evaluation of the activity and function of natural products, and provides theoretical support for the systematic evaluation of the anti-osteoporosis activity of the bone peptide and the development of the bone peptide product with biological activity.

Description

technical field [0001] The invention belongs to the field of nutrition and functional food, relates to a biomarker in osteoporosis intervention therapy, also relates to a screening method for biomarkers of osteoporosis anti-osteoporosis activity, and also relates to an osteopeptide intervention treatment of osteoporosis The use of biomarkers in . Background technique [0002] As my country enters an aging society, the incidence of osteoporosis among residents is also increasing year by year. At present, there are about 93 million osteoporosis patients in my country, and it is predicted that the number of osteoporosis patients will be close to 200 million by 2050. Osteoporosis is a systemic bone metabolic disease characterized by osteopenia, degeneration of bone microstructure, and increased bone fragility. Osteoporosis-induced fractures have increased the morbidity and mortality, and have become a serious public health problem. Clinically, drugs for the treatment of osteo...

AI Technical Summary

Problems solved by technology

At present, a certain degree of research has been carried out on the anti-osteoporosis activity and mechanism of osteopeptide, but only by observing one or a few typical indicators in bone tissue or organs to evaluate its anti-osteoporosis activity. There are great limitations and one-sidedness at the level, and the mechanism of action of osteopeptide cannot be systematically and comprehensively reflected and explained, which greatly limits its development and utilization.

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