The invention belongs to the technical field of precise measuring and the field of optical engineering, and particularly relates to a high-accuracy laser large-working-distance auto-collimation device and method. The device is composed of a laser source, a collimation lens, a reflector and a feedback imaging system. The method includes the steps that the reflector is adjusted, a reflected laser beam returns to the center of the image surface of the feedback imaging system, and then angle changes of the surface of a measured object are obtained through an angle deflection measuring device on the reflector. As the reflector is additionally arranged on a traditional auto-collimation angle measuring system, the problem that as lasers reflected by a measured object deviate from the measuring system, measuring can not be carried out is solved, and then the technical advantage that the auto-collimation working range is expanded with the same working distance or the working distance is increased within the same auto-collimation working range is achieved; in addition, due to the specific design of the collimation lens, the feedback imaging system, the reflector and the like, the device and method have the advantages that the structure is simple, the manufacturing cost is low, the stability of the measuring environment can be monitored, and rapid measuring can be achieved.