The present invention belongs to the precise measurement technology field and the optical engineering field, in particular relates to an array zero setting high-precision laser large-working distance auto-collimation device and method. The device is composed of a light source, a collimating mirror, a reflector and a feedback imaging system, and the method is characterized in that by adjusting the reflector, a reflected light beam returns to the center of an image plane of the feedback imaging system, and then by utilizing an angle deflection measurement device on the reflector, the angle change on the surface of a measured object is obtained. According to the present invention, by adding the reflector on a conventional auto-collimation angle measurement system, the problem that the reflected light of the measured object deviates the measurement system, so that the reflected light of the measured object can not be measured, can be avoided, and further the technical advantage that an auto-collimation working range is increased under a same working distance, or the working distance is increased under the same auto-collimation working range, is realized. In addition, by the concrete design of the devices, such as the collimating mirror, the feedback imaging system, the reflector, etc., the device of the present invention is simple in structure and low in manufacturing cost. Meanwhile, according to the present invention, the technical advantages of being able to monitor and measure environmental stability, and being rapid to measure are realized.