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Method for rapidly determining content of mercaptoacetic acid

A technology for rapid determination of thioglycolic acid, which is applied in chemical analysis by titration, measuring device, and material analysis by observing the influence of chemical indicators. The effect of low adaptability and equipment requirements

Inactive Publication Date: 2020-04-14
中检科健(天津)检验检测有限责任公司
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Problems solved by technology

For the problems existing in the iodometric method of thioglycolic acid in alkaline environment, the possible reason is that there is a contradiction between the influencing factors and the reaction mechanism in the titration

Method used

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  • Method for rapidly determining content of mercaptoacetic acid
  • Method for rapidly determining content of mercaptoacetic acid
  • Method for rapidly determining content of mercaptoacetic acid

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Embodiment 1

[0029] A rapid assay method for thioglycolic acid content, said method comprising the steps of: adding 0.0221g of thioglycolic acid into 50mL of 1mol / L sodium hydroxide solution, stirring at about 1000rpm for 60s, then adding 8.5mL of precoloured solution, and then stirring at 1000rpm Stir and react for 20 minutes, after the completion of the stirring, use iodine standard titration solution for titration, stay for 20 s after every 1 drop, measure the solution potential with a composite electrode, stop titration after the obtained potential is greater than 20% of the theoretical value, and draw the potential change curve, Such as figure 1 As shown, the titration end point was determined to be 14.302 mL, and the content of thioglycolic acid was 99.337% when substituted into the stoichiometric equation.

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Abstract

The invention provides a method for rapidly determining the content of mercaptoacetic acid. The method comprises the following steps: oxidizing sulfydryl by iodine under an alkaline condition; limiting the reaction speed through IO3<->generated by reaction; and determining the titration end point to obtain the content of mercaptoacetic acid. According to the method for rapidly determining the content of mercaptoacetic acid, the recovery rate of a mercaptoacetic acid titration method reaches 98%; meanwhile, the method is stable.

Description

technical field [0001] The invention belongs to the field of cosmetics, in particular to a rapid determination method for thioglycolic acid content. Background technique [0002] Thioglycolic acid is the main raw material of daily cosmetic cold perm essence and depilatory agent. The content determination method under 3.9 Thioglycolic acid in Cosmetics Technical Specifications (2015 Edition) is high performance liquid chromatography, ion chromatography and titration. Thioglycolic acid has strong acidity, and requires a very low pH value to achieve better chromatographic behavior under reversed-phase chromatography conditions. Too low pH can reduce column life and increase detection cost. Ion chromatography requires the support of less widespread ion chromatographs. The third analysis method is titration with iodine titration solution in acidic environment. In comparison, the third method is economical and simple, and is very suitable for the determination of the content o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N31/16G01N21/78G01N30/88
CPCG01N31/16G01N21/78G01N30/88
Inventor 周丽丽王雷霍健程建桥刘春艳张喆陈会明
Owner 中检科健(天津)检验检测有限责任公司
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