Application of jak-1 signal pathway inhibitor in preparation of medicine for treating brain injury

A technology of JAK-1 and signaling pathways, applied in the field of biomedicine, can solve problems such as secondary damage and damage, achieve the effect of reducing the degree of neuron degeneration, reducing brain edema, and improving nerve function damage

Active Publication Date: 2021-08-31
SUZHOU UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also, the damage from secondary injuries appears to be more severe and long-lasting

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of jak-1 signal pathway inhibitor in preparation of medicine for treating brain injury
  • Application of jak-1 signal pathway inhibitor in preparation of medicine for treating brain injury
  • Application of jak-1 signal pathway inhibitor in preparation of medicine for treating brain injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Sixty-six 6-8-week-old male C57 / BL6J mice (20-25g) with basically the same body weight were randomly divided into three groups, 22 in each group, respectively: control group (Sha group), Vehicle treatment craniocerebral injury group ( Vehicle group), Ruxolitinib treatment craniocerebral injury group (RUXO group).

[0044] The mice in the control group were fed normally without any treatment. The modeling steps of Vehicle group and RUXO group are as follows:

[0045]The mice in each group were fixed with a stereotaxic instrument, the mouse scalp was cut to expose the skull, the coronal suture and the sagittal suture tangent line were on both sides, and a circular hole with a diameter of 4mm was drilled in the left hemisphere to expose the brain tissue. Then use the air pressure impact quantitative cortical striker to strike to establish a craniocerebral injury model. The Vehicle group was intraperitoneally injected with 0.01% DMSO (0.2 mL) within 30 minutes after crani...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the application of JAK-1 signaling pathway inhibitors in the preparation of drugs for treating brain injury and / or protecting brain nerves. Inhibitors of the JAK‑1 signaling pathway (one of which is Ruxolitinib, a clinical drug approved by the FDA for the treatment of myelofibrosis) exert neuroprotective effects by (but not limited to) inhibiting the process of pyroptosis. Injured patients provide new theoretical and technical means.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of a JAK-1 signaling pathway inhibitor in the preparation of a drug for treating brain injury. Background technique [0002] At present, craniocerebral injury is very common clinically, such as traumatic brain injury (traumatic brain injury, TBI), which has a high mortality and disability rate, and is especially common in young people, causing a great burden to society. Conditions following brain injury are rapid, complex, and prolonged. Although the drugs and surgical operations for the treatment of brain injury are improving day by day, effective treatment methods and means are quite scarce, especially the lack of drug treatment means. Therefore, it is imperative to fully study the pathological changes after brain injury in order to seek better treatments. [0003] Taking traumatic brain injury as an example, its pathogenesis is mainly divided into two types, one is...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/519A61P25/00
CPCA61K31/519A61P25/00
Inventor 陶陆阳高诚陈溪萍鄢亚南陶泓旭
Owner SUZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap