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Application of 6-gingerol in neonatal hypoxic-ischemic encephalopathy (HIE)

A technology for hypoxia-ischemia and newborns, which can be applied in the fields of cardiovascular system diseases, nervous system diseases, drug combinations, etc., and can solve problems such as the effect of 6-gingerol that has not been reported in research

Active Publication Date: 2020-05-08
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the inventors found that there is no research report on the role of 6-gingerol in HIE

Method used

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  • Application of 6-gingerol in neonatal hypoxic-ischemic encephalopathy (HIE)
  • Application of 6-gingerol in neonatal hypoxic-ischemic encephalopathy (HIE)
  • Application of 6-gingerol in neonatal hypoxic-ischemic encephalopathy (HIE)

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Experimental program
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Effect test

Embodiment 1

[0095] Materials and Methods

[0096] 1. HIE model

[0097]Animal experiments were performed in accordance with the International Guidelines for Animal Research provided by the Council of International Medical Organizations (CIOMS), and the procedures were approved by the Animal Ethics and Welfare Committee of Shandong University. The Rice-Vannucci model was used in this study with minor modifications. Briefly, postnatal day 7 (P7) mouse pups were anesthetized with 2-3% isoflurane inhalation, the mouse right common carotid artery was exposed, and double ligated with 4-0 surgical suture. The rats were recovered for 1 hour, and then placed in a hypoxic incubator at 37°C containing 5% carbon dioxide, 9% oxygen and 86% nitrogen for 90 minutes. In the sham operation group, only anesthetized and exposed the right carotid artery, and no carotid arteries were performed. Arterial ligation and hypoxia treatment.

[0098] 2. Intraperitoneal injection of mice and drug treatment

[009...

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Abstract

The invention provides application of 6-gingerol in neonatal hypoxic-ischemic encephalopathy (HIE). According to the application, it is the first time to prove that the 6-gingerol can relieve cerebralinjuries after HIE in neonatal mice, inhibits nerve cell death after the HIE in the neonatal mice, obviously lowers BCL2-associated X (Bax) protein level of a cortex of a lesion side after the HIE, increases expression of B-cell lymphoma-2 (Bcl-2) protein and increases the proportion of Bcl-2 / Bax, and meanwhile, the 6-gingerol can relieve inflammatory reactions after the HIE by reducing expression of pro-inflammatory factors including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) and can improve the short-term nervous reflex and the long-term exercise capacity after the HIE in the mice, and accordingly, the 6-gingerol can be considered to be an effective candidate drug for neuroprotective therapy of the cerebral injuries after the HIE, and has important clinical application value.

Description

technical field [0001] The invention belongs to the technical field of crude drugs and medicines, and in particular relates to the application of 6-gingerol in neonatal hypoxic-ischemic encephalopathy. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] In recent years, with the continuous improvement and continuous development of medical care, prenatal and neonatal care has been improved, but neonatal hypoxic ischemic encephalopathy (hypoxic ischemic encephalopathy) is still the leading cause of neonatal morbidity and mortality worldwide. One of the important reasons is that in developed countries, the incidence rate is 2 to 3 cases per 1,000 newborns, which seriously affect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61P25/00A61P9/10
CPCA61K31/12A61P9/10A61P25/00
Inventor 郝爱军周文娟赵曼杜静怡
Owner SHANDONG UNIV