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Physiological poison metabolism kinetic model of adult female orally exposed to PCBs

A dynamic model and dynamic technology, applied in the field of public health, can solve problems such as ignoring racial differences, ignoring the accumulation of PCBs, and ignoring the metabolism of characteristic populations, etc., to achieve the effect of accurate assessment

Inactive Publication Date: 2020-05-12
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The accumulation and health effects of PCBs in adults depend on physiological and biochemical factors such as the metabolic level and body fat content of the human body, and female breast tissue is the characteristic accumulation site of PCBs, which does not consider ethnic differences and is not included in the metabolism of characteristic populations. , body fat and other data, without considering the accumulation of PCBs in breast milk, the established physiological toxicokinetic models of PCBs are not applicable to Chinese adult women

Method used

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  • Physiological poison metabolism kinetic model of adult female orally exposed to PCBs
  • Physiological poison metabolism kinetic model of adult female orally exposed to PCBs
  • Physiological poison metabolism kinetic model of adult female orally exposed to PCBs

Examples

Experimental program
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Embodiment 1

[0037] This embodiment discloses a method for constructing a physiological toxicokinetic model of adult females exposed to PCBs orally, including:

[0038] S1: To determine the kinetics of absorption, distribution, metabolism and excretion of orally ingested PCBs in adult females;

[0039] S2: Determine the structure of a physiological toxicokinetic model for oral exposure of adult females to PCBs;

[0040] S3: Establish mathematical models and write differential equations;

[0041] S4: Obtain physiological parameters, PCBs biochemical parameters and PCBs toxicokinetic parameters of adult females;

[0042] S5: Obtain the physiological toxicokinetic model of PCBs.

[0043] For the construction process of the physiological toxicokinetic model of PCBs, see figure 1 ,Proceed as follows:

[0044] 1. Determination of the kinetic process of absorption, distribution, metabolism and excretion of orally ingested PCBs in adult women

[0045] Through literature search and data analys...

Embodiment 2

[0063] This example discloses a physiological toxicokinetic model of adult females exposed to PCBs, which is obtained according to the construction method described in Example 1. The application of this model is as follows:

[0064] Simulate the scenario of long-term oral intake of PCBs by women aged 20-50: Since PCBs are highly accumulative chemicals, the EDI value is used as the daily intake, and adult females are simulated for 30 years of continuous intake. Change trend of PCB content in each target organ and target tissue. 6 kinds of indicative PCBs (PCB28, PCB52, PCB101, PCB138, PCB153, PCB180) were detected in the data of the fifth total diet study in China, and the EDI values ​​of 6 kinds of indicative polychlorinated biphenyls were calculated according to the data of the study It is 36.69ng / day, and the model running time is set to 30 years, that is, 24*365*30 hours. The result is as image 3 , Figure 4 and Figure 5 shown.

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Abstract

The invention relates to the field of public health, in particular to chemical risk assessment, and especially relates to a physiological poison metabolism kinetic model for adult female orally exposed to polychlorinated biphenyls (PCBs). The construction method of the model comprises the following steps: S1, determining a kinetic process of absorption, distribution, metabolism and excretion of PCBs ingested orally in adult female; S2, determining a physiological poison metabolism kinetic model structure of the adult female orally exposed to PCBs; S3, establishing a mathematical model, and compiling a differential equation; S4, obtaining adult female physiological parameters, PCBs biochemical parameters and PCBs toxicokinetic parameters; S5, obtaining a physiological poison metabolism kinetic model of the PCBs. The physiological poison metabolism kinetic model disclosed by the invention can predict the content level and the time change trend of PCBs in multiple organs (liver, fat and the like) and milk in the adult female body based on the PCBs external exposure dose, and is beneficial to more accurately evaluating the health risk that the adult female is exposed to PCBs through the mouth.

Description

technical field [0001] The invention relates to the field of public health, in particular to chemical risk assessment. In particular, it relates to a physiological toxicokinetic model of adult female oral exposure to PCBs. Background technique [0002] Polychlorinated biphenyls (PCBs) are a class of chlorinated biphenyl aromatic hydrocarbon compounds with 209 homologues. The physical and chemical properties of this kind of substance are highly stable, and it is extremely difficult to dissolve in water, but it is soluble in various organic solvents, has high lipophilicity, and can be enriched in a large amount in biological fat. PCBs have the basic characteristics of persistence, bioaccumulation and long-distance atmospheric transport, and are a class of persistent organic pollutants (Persistent organic pollutants, POPs), with a half-life of 9 to 12 years in soil. Polychlorinated biphenyls are widely used as hydraulic oil, insulating oil, heat carrier and lubricating oil, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B5/00G16H50/50
CPCG16B5/00G16H50/50
Inventor 周颖胡曼何更生
Owner FUDAN UNIV
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