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A kind of biological detection device and method

A technology for biological detection and biomolecules, applied in measurement devices, instruments, polarization effects, etc., can solve the problems of low adsorption capacity of biological small molecules and inability to perform interaction analysis, and achieve the effect of high sensitivity

Active Publication Date: 2021-07-30
TSINGHUA UNIV
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Problems solved by technology

[0007] This application is used to solve the problems of low adsorption capacity of existing small biomolecules and the inability to perform interaction analysis, and proposes a detection device and method based on potential modulation for small biomolecules

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  • A kind of biological detection device and method
  • A kind of biological detection device and method
  • A kind of biological detection device and method

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Embodiment Construction

[0018] The specific implementation manners of the present application will be further described in detail below in conjunction with the drawings and embodiments. The following examples are used to illustrate the application, but not to limit the scope of the application.

[0019] In one embodiment of the present application, a biological detection device is provided, which utilizes potential-modulated total internal reflection ellipsometry to detect the adsorption of biomolecules on the sensing surface in real time, which can be used to study biomolecules on solid-phase surfaces Physical and chemical reactions of interactions.

[0020] In one embodiment, such as figure 1 As shown, a biological detection device includes a total internal reflection ellipsometry imager, a potential modulation reaction cell and a photoelectric coupling unit. Among them, the total internal reflection ellipsograph is used to detect the physical and chemical reactions of biomolecular interactions o...

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Abstract

The present application discloses a biological detection device and detection method. The device includes: a total internal reflection ellipsometry imager, which is used to generate a detection beam, and detect the physical and chemical reactions of the interaction of biomolecules on the solid phase surface in real time; It is used to provide the potential conditions required for the electrostatic adsorption of biomolecules on the solid phase surface; the photoelectric coupling unit is used for the physical and chemical reactions of biomolecular interactions on the solid phase surface and for real-time photoelectric composite detection. Based on the potential modulation effect, the present application can observe the adsorption of charged biomolecules on the solid phase surface and its physicochemical reaction in real time.

Description

technical field [0001] The present application relates to the technical field of biological detection, in particular to a biological detection device and method, which are more suitable for the biological detection of small biological molecules. Background technique [0002] The analysis of biomolecular interactions is of great significance for revealing the molecular mechanism of life processes. However, the large number of biomolecules requires high-throughput analysis tools to systematically analyze the interactions between biomolecules. [0003] Currently common optical biosensing technologies include oblique incidence reflection difference scanning imaging devices, reflection interference spectroscopy imagers and resonant waveguide grating sensors, etc. However, it is difficult for the above-mentioned centralized technologies to achieve or achieve the desired effect for effective solutions for the detection of small molecules or low-concentration proteins. [0004] In ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/21
CPCG01N21/211G01N2021/212
Inventor 王晓红刘巍徐思行
Owner TSINGHUA UNIV
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