Use of ip-10 inhibitors in the prevention and/or treatment of Zika virus infection

1. IP-10, Zika virus technology, applied in the application field of IP-10 inhibitors, prevention and/or treatment of Zika virus infection, can solve the problems such as no research reports on the role of IP-10, and achieve prevention And/or the effect of treating Zika virus infection, obvious antiviral effect

Active Publication Date: 2022-07-01
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, IP-10 / CXCL-10 belongs to the CXC chemokine family, which can induce the chemotaxis of immune cells, but at this stage, no research has reported the role of IP-10 in the process of Zika virus infection

Method used

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  • Use of ip-10 inhibitors in the prevention and/or treatment of Zika virus infection
  • Use of ip-10 inhibitors in the prevention and/or treatment of Zika virus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take different ZIKV virus strains, Cambodia ZIKV (GenBank accession number is KU955593.1), SZ01 (GenBank accession number is KU866423) and GZ01 (GenBank accession number is KU820898), with 10 5 5-6 weeks old immunocompetent C57 mice and IP-10-deficient C57 mice were subcutaneously infected at the dose of PFU per mouse. After 24 hours of infection, blood was collected from the tail vein, left at room temperature for 1 hour, centrifuged at 6000 rpm / min for 20 minutes, and then the serum was separated, and the ZIKV viral load in the blood of mice was detected by real-time quantitative PCR (refer to Xiaofeng LI et al., Characterization of a 2016 Clinical Isolate of ZikaVirus). in Non-human Primates, EBioMedicine 12 (2016) 170–177 Methods for the detection of ZIKV by real-time quantitative PCR). The result is as figure 1 shown, from figure 1 It can be seen that viremia can be detected in normal C57 mice 24h after infection with different ZIKV virus strains, but IP-KO mice ...

Embodiment 2

[0031] One day before the infection of pregnant mice, the IP-10 antibody-treated group was administered 100 μg / mice via tail vein injection, while the PBS control group was treated with the same volume of PBS, with 2 rats in each group. 24h after treatment, the pregnant mice in the antibody-treated group and the PBS control group (gestational period E13.5 days) were infected by intraperitoneal route for 10 5 PFU / dose of ZIKV only. 24h after infection, the antibody-treated group was re-injected with 100 μg / rabbit via the tail vein, and the PBS control group was injected with the same volume of PBS via the tail vein. Blood was collected from the two groups of pregnant mice through the tail vein at 48 hours after infection, and the pregnant mice were dissected at 72 hours after infection, and the placenta was collected to detect the viral load in serum and placenta. The result is as figure 2 shown, from figure 2 It can be seen that 48h after infection, viremia could not be d...

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Abstract

The invention relates to the field of viral infection treatment, and discloses the application of IP-10 inhibitor in preventing and / or treating flavivirus infection. By using IP-10 inhibitor, the present invention can effectively prevent and / or treat Zika virus infection, and has obvious antiviral effect.

Description

technical field [0001] The present invention relates to the field of viral infection treatment, in particular to the application of IP-10 inhibitors in preventing and / or treating Zika virus infection. Background technique [0002] Zika virus (ZIKV) is an important member of the Flaviviridae family, a single-stranded positive-stranded RNA virus, as well as dengue virus and yellow fever virus. It is one of many mosquito-borne viruses. Since May 2015, ZIKV outbreaks have occurred one after another in Brazil, Venezuela and other Latin American regions. Due to the outbreak of the outbreak, the number of local neonatal microcephaly (Microcephaly) cases has increased, causing widespread concern around the world. In February 2016, the World Health Organization officially declared the Zika outbreak a "public health emergency of international concern". [0003] Due to the wide scope and serious complications of the Zika epidemic, the research on a series of ZIKV candidate vaccines an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61K39/395A61P31/14
CPCA61K45/00A61K39/3955A61P31/14Y02A50/30
Inventor 秦成峰黄星耀纪雪陈奇
Owner ACADEMY OF MILITARY MEDICAL SCI
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