Working electrode of glucose monitoring probe and manufacturing method thereof

A technology of working electrodes and monitoring probes, which is applied to measuring devices, diagnostic records/measurements, and material analysis through electromagnetic means, which can solve the problems of reduced sensitivity and short service life of implanted continuous glucose detectors, and achieve extended The effect of service life

Active Publication Date: 2020-06-09
SHENZHEN SISENSING TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, implantable continuous glucose monitors often have a short service life and are susceptible to immune reactions in the body and other impurities in the blood that reduce sensitivity

Method used

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  • Working electrode of glucose monitoring probe and manufacturing method thereof
  • Working electrode of glucose monitoring probe and manufacturing method thereof
  • Working electrode of glucose monitoring probe and manufacturing method thereof

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Embodiment Construction

[0031] Hereinafter, preferred embodiments of the present disclosure will be described in detail with reference to the drawings. In the following description, the same reference numerals are given to the same components, and repeated descriptions are omitted. In addition, the drawings are only schematic diagrams, and the ratio of dimensions between components, the shape of components, and the like may be different from the actual ones.

[0032]In addition, subheadings and the like involved in the following description of the present disclosure are not intended to limit the content or scope of the present disclosure, but are merely used as a reminder for reading. Such subtitles can neither be understood as used to divide the content of the article, nor should the content under the subtitle be limited to the scope of the subtitle.

[0033] figure 1 It is a schematic diagram showing the state of use of the glucose monitoring probe according to the embodiment of the present discl...

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Abstract

The present disclosure relates to a working electrode for a glucose monitoring probe, the working electrode comprising: a base layer provided on a flexible substrate; a sensing layer formed on the base layer by coating a sensing layer reagent, the sensing layer being capable of chemically reacting with glucose in blood or tissue fluid, the sensing layer reagent comprising a metal polymer, a glucolase, a carbon nanotube, and a cross-linking agent, the carbon nanotube adsorbing the metal polymer and the glucolase, amino modification is added to the carbon nano tube, so that the metal polymer andthe carbon nano tube tightly form covalent bond combination and are combined with glucolase; a semipermeable membrane is formed on the sensing layer and is used for controlling the passing rate of glucose molecules; and a biocompatible membrane formed on the semipermeable membrane. According to the invention, the working voltage of the working electrode can be reduced, the interference is reduced, the service life of the glucose monitoring probe is prolonged, and the reaction sensitivity to glucose is improved.

Description

technical field [0001] The disclosure relates to the field of glucose monitors, in particular to a working electrode of a glucose monitoring probe and a manufacturing method thereof. Background technique [0002] Biosensors are analytical devices that closely combine biological materials, biologically derived materials, or biomimetic materials with optical, electrochemical, temperature, piezoelectric, magnet, or micromechanical physicochemical sensors or sensing microsystems. To date, the most commercially successful biosensor is the amperometric enzymatic glucose sensor. The market share of amperometric enzymatic glucose sensors is almost 85% of the global market today. The larger the market share of the amperometric enzymatic glucose sensor used to detect diabetes, the larger the number of people with diabetes. [0003] Diabetes is a syndrome of a series of metabolic disorders of sugar, protein, fat, water and electrolytes, which is caused by various pathogenic factors s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/1486G01N27/327
CPCG01N27/3272G01N27/3273A61B5/14865A61B5/14532A61B2562/12A61B2562/164
Inventor 方骏飞郭盼韩明松夏斌赵瑜
Owner SHENZHEN SISENSING TECH CO LTD
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