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Metal organic framework material for enhancing combination of chemodynamic therapy and hunger therapy as well as preparation method and application thereof

A technology of metal-organic frameworks and enhanced chemistry, which is applied in the direction of biochemical equipment and methods, organic active ingredients, and medical preparations of non-active ingredients, can solve the problems that are not enough to achieve satisfactory chemical kinetic efficacy, and achieve enhanced chemical kinetics Effect, good development prospects, good biocompatibility

Inactive Publication Date: 2020-06-09
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, tumor cells' own endogenous H 2 o 2 Not sufficient to achieve satisfactory chemokinetic efficacy

Method used

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  • Metal organic framework material for enhancing combination of chemodynamic therapy and hunger therapy as well as preparation method and application thereof
  • Metal organic framework material for enhancing combination of chemodynamic therapy and hunger therapy as well as preparation method and application thereof
  • Metal organic framework material for enhancing combination of chemodynamic therapy and hunger therapy as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Using 2-methylimidazole and zinc nitrate hexahydrate to synthesize ZIF-8 by co-precipitation at room temperature, and wrapping glucose oxidase (GOx) inside MOFs, the specific synthetic route is as follows:

[0037] Dissolve 410mg of 2-methylimidazole in 4mL of ultrapure water, add 1mL of 10mg / mL glucose oxidase ultrapure aqueous solution, and keep stirring, dissolve 37mg of zinc nitrate hexahydrate in 1mL of ultrapure water, drop by drop Add it into the reaction system, react at 25°C for 1 hour, wash the product three times with ultrapure water, centrifuge at 10,000 r / min for 7 minutes, and dry it in a vacuum oven at 37°C for 12 hours to obtain a light yellow powder product. Dissolve 50mg of light yellow powder in 10mL of ultrapure water, add 20μL of 0.15M manganese sulfate monohydrate ultrapure aqueous solution, add 20μL of 0.1M potassium permanganate ultrapure aqueous solution, react for 15min, and wash the product three times with ultrapure water, 10000r / Centrifuge ...

Embodiment 2

[0048] Using 2-methylimidazole, zinc nitrate hexahydrate and copper nitrate hexahydrate to synthesize copper-doped Cu / ZIF-8 by co-precipitation method at room temperature, and wrap glucose oxidase (GOx) inside MOFs, the specific synthesis The route is as follows:

[0049] Dissolve 1.62g of 2-methylimidazole in 20mL of ultrapure water, add 1mL of 25mg / mL glucose oxidase ultrapure aqueous solution, and keep stirring, dissolve 370mg of zinc nitrate hexahydrate and 370mg of copper nitrate hexahydrate in 1mL Add ultrapure water dropwise to the reaction system, stir and react at 25°C for 1h, wash the product with ultrapure water three times, centrifuge at 10000r / min for 7min, and dry in a vacuum oven at 37°C for 12h to obtain a powder product. Dissolve 50mg of light yellow powder in 10mL of ultrapure water, add 20μL of 0.15M manganese sulfate monohydrate ultrapure aqueous solution, add 20μL of 0.1M potassium permanganate ultrapure aqueous solution, react for 15min, and wash the pro...

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Abstract

The invention discloses a metal organic framework material for enhancing combination of chemodynamic therapy and hunger therapy as well as a preparation method and application thereof, wherein the material can decompose excessive glutathione in a tumor microenvironment to generate metal ions capable of catalyzing Fenton-like reaction. A pH-responsive metal-organic framework material ZIF-8 is usedfor in-situ growth and is coated with a substance capable of decomposing glucose, and the surface of the material is modified with a metal oxide, so that a composite material system is obtained. The metal oxide can react with glutathione to generate metal ions, ZIF-8 is decomposed to release drugs or biological enzymes under the condition of low pH, glucose can be decomposed to generate hydrogen peroxide, and the metal ions subjected to Fenton-like reaction catalyze hydrogen peroxide to generate toxic .OH, so that the effect of combining chemodynamic therapy and hunger therapy is achieved. Thematerial system is good in biocompatibility, reduces the toxic effect of traditional chemical drug therapy on normal cells, and is expected to be applied to cancer treatment in the future.

Description

Technical field [0001] The present invention involves the use of a common metal organic framework material, by loading drugs or biological enzymes that can decompose glucose inside, and modifying metal oxides that can decompose glutathione on the outside, to construct a structure that can realize starvation and chemical kinetics Material system for synergistic treatment. Realize the combination of hunger treatment and chemodynamic treatment, reduce the use of chemical drugs and reduce side effects. Background technique [0002] Cancer refers to malignant tumors originating from epithelial tissue. Cancer has biological characteristics such as abnormal cell differentiation and proliferation, uncontrolled growth, invasion, and metastasis. Its occurrence is a multi-factor and multi-step complex process. There are three processes of carcinogenesis, cancer promotion and evolution. In February 2018, the National Cancer Center released China's latest cancer data, which summarized ...

Claims

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Application Information

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IPC IPC(8): C08G83/00A61K38/44A61K47/34A61K31/555A61P35/00
CPCA61K31/555A61K38/443A61K47/34A61P35/00C08G83/008C12Y101/03004
Inventor 钱国栋王杰崔元靖杨雨
Owner ZHEJIANG UNIV
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