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A non-uniform grid optimization method for bioreactor flow control

A non-uniform grid, bioreactor technology, used in biochemical equipment and methods, microbial determination/inspection, adaptive control, etc., can solve problems such as reducing grids, reduce consumption, and increase production and productivity. , improve the effect of optimization efficiency

Active Publication Date: 2021-06-18
JIANGNAN UNIV
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  • Application Information

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Problems solved by technology

Combining the existing methods, the grid is often subdivided and refined mathematically. How to reduce the grid from an engineering point of view and combine the specific fermentation growth stages with gridding has not been involved.

Method used

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  • A non-uniform grid optimization method for bioreactor flow control
  • A non-uniform grid optimization method for bioreactor flow control
  • A non-uniform grid optimization method for bioreactor flow control

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Embodiment Construction

[0058] Refer below figure 1 The specific implementation manners of the present invention will be further described.

[0059] First, the yield of metabolites in the fermentation process is taken as the optimization target, the feeding rate u(t) is taken as the manipulated variable to be optimized, and some engineering and empirical requirements in the actual fermentation production are taken as constraints, and the t 0 = 0 to the end time t f During the entire cycle of , seek the optimal feeding rate control trajectory u * (t), so that the objective function J at the end of fermentation is maximized.

[0060] Divide the entire fermentation production cycle into N grid intervals with different widths [t k ,t k+1 ],k=1,...,N, the control trajectory of the feed is linearly combined with the basis functions u in all k grids σ (k) to approximate.

[0061] For the above non-uniformly divided time grid [t k ,t k+1 ], let v(k)=t k -t k-1 Indicates the grid width; introduce a...

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Abstract

The invention discloses a non-uniform grid optimization method for feed regulation of a bioreactor, which belongs to the field of regulation optimization and application of industrial microorganism manufacturing process. It involves an optimization method of substrate flow acceleration rate control trajectory based on the parameterization of non-uniform grid control variables. According to the different requirements of substrate nutrients in different stages of microbial growth and metabolism, the control trajectory of feeding amount is correspondingly adjusted in time The domain is divided into grids with different widths, and the feeding flow acceleration rate and grid width of each segment of the grid are used as variables to be optimized. Through the time domain transformation function, the grid widths of different lengths are mapped to the equal length network In the new time domain of the grid, finally compare the deviation between the optimized time node and the growth stage node in the engineering practice, and give a grid readjustment strategy, with less grid division, to achieve such as maximum product generation, substrate Optimizing goals such as the highest conversion rate to improve optimization effects and efficiency.

Description

technical field [0001] The invention belongs to the field of regulation optimization and application of industrial microorganism manufacturing process, and relates to a method for optimizing the control trajectory of substrate flow acceleration rate based on the parameterization of non-uniform grid control variables. When optimizing the target, the optimization algorithm is more suitable for engineering practice with fewer grid divisions and grid readjustment that is more suitable for the growth stage of microorganisms, ensuring that the bioreactor maintains the optimal substrate concentration to promote the production of metabolites. synthesis. Background technique [0002] With the development of the green economy and the change of market demand, the small-batch, high-profit and multi-variety production methods represented by industrial microbial technology are increasingly valued. Fermentation production using bioreactors can obtain products with high economic benefits w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G05B13/04C12Q3/00
CPCC12Q3/00G05B13/042
Inventor 刘飞石博文尹燕燕李恭新赵忠盖
Owner JIANGNAN UNIV