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Transdermal therapeutic system on the basis of adhesive plasticizer-polymer matrices

A technology of polymers and plasticizers, which is applied in the directions of organic active ingredients, medical preparations containing active ingredients, and sheet delivery, etc., can solve the problems of complex, unfavorable economy and expensive preparations in the preparation method of transdermal therapeutic systems.

Pending Publication Date: 2020-07-03
LTS LOHMANN THERAPIE-SYST AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The transdermal therapeutic systems known from the prior art therefore have the disadvantage that the compatibility of the pharmaceutically active substance with conventionally available adhesive polymers has to be estimated
This often leads to relatively complex and expensive formulations, since possible incompatibilities between active substances and conventional adhesive polymers can only be overcome by adding further auxiliaries, such as further solvents and / or emulsifiers
In addition, the production process of transdermal therapeutic systems with such complex and expensive formulations is economically unfavorable

Method used

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  • Transdermal therapeutic system on the basis of adhesive plasticizer-polymer matrices
  • Transdermal therapeutic system on the basis of adhesive plasticizer-polymer matrices
  • Transdermal therapeutic system on the basis of adhesive plasticizer-polymer matrices

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Embodiment 1

[0051] The following formulations were prepared and applied to polyethylene terephthalate film. All formulations had adhesive properties.

[0052] Table 1: Formulations according to the invention

[0053] Preparation code polymer plasticizer active substance 124Idb0029 80% Soluplus 10%PEG 200 10% Idebenone 13XIdb0011 80% Soluplus 10% glycerin 10% Idebenone 13XIdb0012 70% Soluplus 20% glycerin 10% Idebenone 13XIdb0009 70% Kollidon VA 64 20% glycerin 10% Idebenone 13XIdb0010 60% Kollidon VA 64 30% glycerin 10% Idebenone 13XObu0001 70% Soluplus 20% glycerin 10% Oxybutynin 13XObu0002 70% Soluplus 20%PEG 200 10% Oxybutynin 13XObu0003 65% Soluplus 25%PEG 200 10% Oxybutynin 13XObu0004 60% Soluplus 30%PEG 200 10% Oxybutynin 13XObu0005 65% Kollidon VA 64 25%PEG 200 10% Oxybutynin 13XObu0006 65% Kollidon VA 64 25% glycerin 10% Oxybutynin 13XObu0007...

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Abstract

The present application relates to a transdermal therapeutic system comprising a backing layer impermeable to active substances and a polymer matrix on one side of the backing layer impermeable to active substances, wherein the polymer matrix comprises at least one pharmaceutically active substance, at least one inherently non-self-adhesive polymer and at least one plasticizer, said polymer matrixbeing free of adhesive polymers. The invention further relates to a method of producing the transdermal therapeutic system and to the use thereof as a drug.

Description

technical field [0001] The present invention relates to transdermal therapeutic systems based on adhesive plasticizer polymer matrices, processes for their preparation and their use as medicaments. Background technique [0002] Transdermal therapeutic systems (TTS) have gained widespread use in recent years as a delivery form for the treatment of a variety of diseases due to their advantages over their conventional delivery forms. This consists in particular in the precise and constant administration of the active substance which is necessary for a constant concentration of the active substance in the blood plasma. Furthermore, because the patient does not have to take the pills on a regular basis, first-pass effects are avoided and adherence is increased. An advantage of transdermal therapeutic systems over other topical application systems such as ointments or creams is also that they can be applied area-wise and thus dose-accurately without accidental rubbing off of the ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/506A61K31/216A61K31/122
CPCA61K9/7069A61K9/7076A61K31/122A61K31/216A61K31/506A61K31/381A61K31/4545A61K31/135A61K31/663A61K31/4468A61K31/24
Inventor M·林M·穆勒M·鲍尔
Owner LTS LOHMANN THERAPIE-SYST AG