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Cellulose hollow capsule and capsule preparation thereof

A technology of hollow capsules and cellulose, applied in the field of materials, can solve the problems of easy discoloration, discoloration of capsules, and affecting customers' desire to buy, etc., and achieve the effects of low friability, inhibiting discoloration, and not easy to break

Active Publication Date: 2020-07-10
江苏祺轩新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But most food colorings are extremely easy to change color in the environment of light and oxygen
The discoloration of the capsule will seriously affect the customer's desire to buy

Method used

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  • Cellulose hollow capsule and capsule preparation thereof
  • Cellulose hollow capsule and capsule preparation thereof
  • Cellulose hollow capsule and capsule preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～27、 comparative example 1～2

[0054] According to the formula shown in Table 1, prepare 0# (No. 0) cellulose hollow capsules as follows.

[0055] Step 1: Dissolving Brilliant Blue Pigment (accounting for 0.1 wt% of hydroxypropyl methylcellulose in Step 2) with deionized water at room temperature into a solution;

[0056] Step 2: After heating the solution in step 1 to 95° C., add hydroxypropyl methylcellulose to prepare a solution with a concentration of hydroxypropyl methylcellulose of 25% by weight;

[0057] Step 3: Continue heating the solution in step 2 for 2 to 4 hours to obtain a matrix layer glue solution with a viscosity of about 200,000 mPa·s at 25°C;

[0058] Step 4: Dip the matrix layer glue solution in step 3 with the body mold and cap mold of the 0# capsule, and then dry at 40°C for a certain period of time to obtain the matrix layers of the body and cap respectively. By controlling the amount of glue dipped and the volatilization time, the thickness of the matrix layer of the capsule body an...

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Abstract

The invention provides a cellulose hollow capsule. The cellulose hollow capsule is characterized in that at least one substrate layer and an outer coating layer are contained, wherein the outer coating layer is arranged on the outer side of the substrate layer. The outer coating layer effectively isolates the influence of ultraviolet rays on a pigment and has certain strength, so that query of thequality of a finished product by a client due to easy discoloration is avoided, and the commodity property of the capsule is increased. The method is simple, easy to implement and outstanding in effect. Moreover, no metal ions are used in the cellulose hollow capsule, so that the influence of metal ions on drug dissolution is avoided.

Description

technical field [0001] The invention relates to the field of materials, in particular to a cellulose hollow capsule. Background technique [0002] In order to adapt to treatment or prevention, drugs often need to be prepared into different dosage forms, among which injections, tablets and capsules occupy the main market. With the vigorous development of the global pharmaceutical industry, capsules are due to their good appearance, high research and development efficiency and production costs. Low-level advantages are favored by consumers. For capsules, patients are easy to use and easy to accept. Not only the dosage of drugs is accurate, but also the stability of drugs is increased, and sometimes side effects can be reduced, and it is also convenient for storage, transportation and carrying of drugs, so the proportion of capsules is constantly increasing. At the same time, the main pharmaceutical excipient of capsules-medicinal empty capsules also has a huge development. I...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/22A61K47/38A23L5/41A23L5/47A23L29/262A23P10/30
CPCA61K9/4816A61K47/38A61K9/4891A61K47/22A23P10/30A23L29/262A23L5/41A23L5/47A23V2002/00A23V2250/5108A23V2200/048A23V2200/044
Inventor 桂宗彦何良鑫马雪华
Owner 江苏祺轩新材料科技有限公司