Two-dimensional nano composite material as well as preparation method and application thereof

A technology of nanocomposite materials and nanomaterials, which is applied in the field of its preparation, bismuth oxyhalide nanomaterials, can solve the problems of complex synthesis path, additional biological toxicity, multiple illumination, etc., and achieve the effect of simple process, low cost and environmental friendliness

Active Publication Date: 2020-07-10
CIXI INST OF BIOMEDICAL ENG NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1. Although there have been a large number of literature reports on photothermal therapy excited by near-infrared light, the research on photodynamic therapy excited by near-infrared region is still lagging behind. Many studies use two kinds of laser irradiation, resulting in unnecessary side effects
[0006] 2. In order to obtain simultaneous photothermal and photodynamic effects triggered by near-infrared, many researchers use up-conversion materials (such as lanthanides) to convert near-infrared light into short-wavelength ultraviolet or visible light, thereby exciting photosensitive molecules to generate reactive oxygen species, but Due to the high biological toxicity of this kind of material, its further application is limited.
[0007] 3. Most of the nanomaterials for combined therapy are composed of two or more materials, which have the disadvantages of complex synthetic routes, possible additional biological toxicity, and the need for multiple light exposures
[0010] X-ray computed tomography (CT) is the mainstay of clinical diagnostic methods with high resolution and no depth limitation, however, single CT imaging has various inherent limitations, especially poor soft tissue contrast, low flux and ionizing radiation It also represents a limitation that hinders the application of CT in clinical diagnosis

Method used

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  • Two-dimensional nano composite material as well as preparation method and application thereof
  • Two-dimensional nano composite material as well as preparation method and application thereof
  • Two-dimensional nano composite material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0148] Preparation of White Bismuth Oxyhalide Materials Without Oxygen Vacancies

[0149] (1-1-1) Weigh 486mg Bi(NO 3 ) 3 ·5H 2 0. After mixing 400mgPVP and 455mg mannitol, dissolve it in 25mL ultrapure water, carry out ultrasonic treatment after stirring the mixed solution for 10min to make it evenly mixed, then put it into an ultrasonic machine for ultrasonic 10min to obtain solution a;

[0150] (1-1-2) Subsequently, in the process of continuous stirring, 5 mL of saturated NaCl solution was slowly added dropwise into the mixed solution through a syringe, and stirred while dropping. After the dropwise addition, a uniform white suspension b was obtained;

[0151] (1-1-3) The white suspension b was ultrasonically diffused again for 10 minutes, and then the mixed solution was transferred to a 50ml polytetrafluoroethylene hydrothermal reaction kettle, and then hydrothermally reacted at 160°C for 3 hours, naturally After cooling, the precipitate was washed with water and eth...

Embodiment 2

[0182] Gray bismuth oxyhalide materials with a small number of oxygen vacancy defects and Bismuth Oxyhalide Nanomaterials with More Oxygen Vacancies (Black) preparation of

[0183] (2-2-1) Weigh 0.97g Bi(NO 3 ) 3 ·5H 2 O with 0.315g BiCl 3 Dissolve in 40mL DEG, place it on a magnetic stirrer, and stir continuously at a speed of 80r / min for 10min, then put it into an ultrasonic machine and sonicate for 10min to obtain solution d;

[0184] (2-2-2) Move the solution d into the polytetrafluoroethylene liner of the hydrothermal reaction kettle, and react at 160° C. for 12 hours;

[0185] After the reaction, wait for cooling to room temperature, remove the supernatant, leave the precipitate and wash it with water and ethanol for 4 times, then dry it to obtain the bismuth oxyhalide material e with some oxygen vacancies (grey) for later use, which is designated as sample 2-2;

[0186] (2-2-3) Take 50 mg of bismuth oxyhalide material e powder with partial oxygen vacancies (gray...

Embodiment 3

[0192] Gray bismuth oxyhalide materials with a small number of oxygen vacancy defects and Bismuth Oxyhalide Nanomaterials with More Oxygen Vacancies (Black) preparation of

[0193] (3-2-1) Weigh 0.97g Bi(NO 3 ) 3 ·5H 2 O with 0.315g BiCl 3 Dissolve in 40mL DEG, place it on a magnetic stirrer, and stir continuously at a speed of 80r / min for 10min, then put it into an ultrasonic machine and sonicate for 10min to obtain solution d;

[0194] (3-2-2) Move the solution d into the polytetrafluoroethylene liner of the hydrothermal reaction kettle, and react at 140° C. for 12 hours;

[0195] After the reaction, wait for cooling to room temperature, remove the supernatant, leave the precipitate, wash it with water and ethanol for 4 times, and then dry it to obtain the bismuth oxyhalide material e with partial oxygen vacancies (gray), which is designated as sample 3-2;

[0196] (3-2-3) Take 50 mg of bismuth oxyhalide material e powder with partial oxygen vacancies (gray) and disp...

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Abstract

The invention discloses a nano composite material which comprises BiOX particles and a coating, wherein the BiOX particles have oxygen vacancy defects; and the coating is a biocompatible material. under near-infrared radiation, the photothermal conversion efficiency of the nano composite material is greater than or equal to 10%; under near-infrared radiation, the velocity that 1,3-diphenyl isobenzofuran is degraded by the nano composite material is greater than or equal to 0.1mmol / h; and BiOX is selected from at least one of BiOF, BiOCl, BiOBr, BiOI and BiOAt. The invention further discloses apreparation method and application of the nano composite material. The nano composite material is a bismuth oxyhalides nano material with oxygen vacancy defects at different concentrations, and is applied to photothermal treatment on tumors; and the nano composite material is applied to integration of diagnosis and treatment on tumors, and is a diagnosis and treatment integral reagent which is good in treatment effect and excellent in CT (computed tomography) imaging and photoacoustic imaging performance, distinguishing and detection on critical illnesses such as tumors can be improved, and functions of follow-up treatment, treatment effect tracking, prognosis evaluation, and the like, can be achieved.

Description

technical field [0001] The invention relates to the field of materials, in particular to a two-dimensional bismuth oxyhalide nanomaterial with different oxygen vacancy defects, a preparation method and application thereof. Background technique [0002] Malignant tumors have always been known as the number one killer of human health. According to incomplete statistics, 9.6 million patients die of cancer and 18.1 million new cases are diagnosed every year in the world. In view of the high risk of cancer and high mortality, researchers around the world have been working on developing more accurate and rapid diagnostic methods and treatments to fight cancer. Traditional cancer treatment includes chemotherapy, radiotherapy and surgery. In these traditional treatments, patients may suffer from severe side effects: chemotherapy and radiotherapy are less targeted and can cause serious damage to normal tissues and organs; Malignant tumors are helpless. The failure of these treatme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/04A61K49/22A61K9/50A61K47/18A61P35/00A61P35/04
CPCA61K41/0052A61K41/0057A61K41/0038A61K49/0438A61K49/0485A61K49/22A61K49/225A61K9/5123A61P35/00A61P35/04B82Y30/00B82Y40/00A61K41/0042B82Y5/00
Inventor 吴爱国陈天翔房倩兰
Owner CIXI INST OF BIOMEDICAL ENG NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI
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