A kind of two-dimensional nanocomposite material, its preparation method and application

Abstract

The invention discloses a nanocomposite material, comprising BiOX particles with oxygen vacancy defects and a coating; the coating is a biocompatible material; under near-infrared light, the photothermal conversion efficiency of the nanocomposite is ≥ 10%; under near-infrared light, the nanocomposite material degrades 1,3-diphenylisobenzofuran at a rate of ≥0.1mmol / h; BiOX is selected from at least one of BiOF, BiOCl, BiOBr, BiOI, and BiOAt . The preparation method and application of the nanocomposite material. The material has different concentrations of oxygen vacancy defects of bismuth oxyhalide nanomaterials, which are used in photothermal therapy of tumors; applied in the integration of tumor diagnosis and treatment, with good therapeutic effect under the guidance of multi-modal imaging, and excellent performance of CT imaging and photoacoustic imaging Reagents integrating diagnosis and treatment can improve the identification and detection of major diseases such as tumors, and realize the functions of follow-up treatment, tracking treatment effect and prognosis evaluation.

Description

technical field [0001] The invention relates to the field of materials, in particular to a two-dimensional bismuth oxyhalide nanomaterial with different oxygen vacancy defects, a preparation method and application thereof. Background technique [0002] Malignant tumors have always been known as the number one killer of human health. According to incomplete statistics, 9.6 million patients die of cancer and 18.1 million new cases are diagnosed every year in the world. In view of the high risk of cancer and high mortality, researchers around the world have been working on developing more accurate and rapid diagnostic methods and treatments to fight cancer. Traditional cancer treatment includes chemotherapy, radiotherapy and surgery. In these traditional treatments, patients may suffer from severe side effects: chemotherapy and radiotherapy are less targeted and can cause serious damage to normal tissues and organs; Malignant tumors are helpless. The failure of these treatme...

AI Technical Summary

Problems solved by technology

[0005] 1. Although there have been a large number of literature reports on photothermal therapy excited by near-infrared light, the research on photodynamic therapy excited by near-infrared region is still lagging behind. Many studies use two kinds of laser irradiation, resulting in unnecessary side effects

[0006] 2. In order to obtain simultaneous photothermal and photodynamic effects triggered by near-infrared, many researchers use up-conversion materials (such as lanthanides) to convert near-infrared light into short-wavelength ultraviolet or visible light, thereby exciting photosensitive molecules to generate reactive oxygen species, but Due to the high biological toxicity of this kind of material, its further application is limited.

[0007] 3. Most of the nanomaterials for combined therapy are composed of two or more materials, which have the disadvantages of complex synthetic routes, possible additional biological toxicity, and the need for multiple light exposures

[0010] X-ray computed tomography (CT) is the mainstay of clinical diagnostic methods with high resolution and no depth limitation, however, single CT imaging has various inherent limitations, especially poor soft tissue contrast, low flux and ionizing radiation It also represents a limitation that hinders the application of CT in clinical diagnosis

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