Unlock instant, AI-driven research and patent intelligence for your innovation.

Alkynyl phosphonic acid alkyl tin complex with antitumor activity and application thereof

A technology of tin alkynyl phosphonate and anti-tumor activity, which can be used in anti-tumor drugs, organic active ingredients, medical preparations containing active ingredients, etc., and can solve the problem of less research on pharmacological activity and less research on the anti-tumor activity of complexes And other issues

Inactive Publication Date: 2020-07-10
台州泰捷化工科技有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There have been literature reports on the research on the hydrocarbyl tin complexes of alkynylphosphonic acid, but these literatures mostly focus on the synthesis and structure research stage, and there are few studies on pharmacological activity, and most of them are tested for their bactericidal and acaricidal activities. , there are few studies on the antitumor activity of such complexes

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Alkynyl phosphonic acid alkyl tin complex with antitumor activity and application thereof
  • Alkynyl phosphonic acid alkyl tin complex with antitumor activity and application thereof
  • Alkynyl phosphonic acid alkyl tin complex with antitumor activity and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 3

[0016] Synthesis of embodiment 1 tri-n-butyltin (IV) (3,5-dimethylphenyl) ethynyl phosphonic acid derivative

[0017]

[0018] The structural formula of the product is:

[0019] In a 100mL round bottom flask, add 3mmol tri-n-butyltin chloride and 20mL anhydrous methanol, stir, after tributyltin chloride is completely dissolved, add 3.2mmol (3,5-dimethylphenyl) acetylene monosodium phosphate, stirred and reacted for 5 hours under reflux, cooled, filtered, the filtrate was concentrated under reduced pressure, an appropriate amount of petroleum ether was added and filtered, and concentrated in vacuo to obtain the product with a yield of 85%.

[0020] Elemental analysis data: Anal.Calcd.For C 22 h 37 o 3 PSn (%): C 53.02, H 7.58, Sn 23.95; Found (%): C 52.98, H 7.41, Sn 23.69. H NMR spectrum data: 1 H NMR / δ 0.79-0.83(15H), 1.24-2.03(18H), 7.21-7.89(3H).

Embodiment 2

[0022] According to the method of Example 1, monosodium phenylethynyl phosphate was selected as a raw material to prepare tri-n-butyltin (IV) phenylethynylphosphonic acid derivatives.

Embodiment 3

[0023] The antitumor activity test of embodiment 3 compound

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an alkynyl phosphonic acid alkyl tin complex with antitumor activity and application thereof. The activity of the alkynyl phosphonic acid alkyl tin complex is tested so that thealkynyl phosphonic acid alkyl tin complex has much stronger activity than cis-platinum and is a potential candidate for clinical antitumor drugs.

Description

technical field [0001] The invention relates to a hydrocarbyl tin complex of alkynyl phosphonic acid with antitumor activity, belonging to the field of medicinal chemistry. Background technique [0002] Phosphine (phosphoric) acid derivatives of hydrocarbyl tin have strong biological activities such as insecticidal, bactericidal and herbicidal, and have received great attention from people. There have been literature reports on the research on the hydrocarbyl tin complexes of alkynylphosphonic acid, but these literatures mostly focus on the synthesis and structure research stage, and there are few studies on pharmacological activity, and most of them are tested for their bactericidal and acaricidal activities. , There are few studies on the antitumor activity of this kind of complexes. [0003] Tin complexes usually have certain anti-tumor activity. Based on this consideration, in order to explore new anti-cancer drugs, we carried out an investigation on the existing litera...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/38A61P35/00A61K31/662
CPCC07F9/38A61P35/00C07F9/4053C07F9/3826
Inventor 金建德
Owner 台州泰捷化工科技有限公司