Virgate wormwood herb-cape jasmine fruit-baical skullcap root microcapsule preparation and preparation method thereof

A technology of Yinzhihuang and its preparation, which is applied in the field of Yinzhihuang microcapsule preparation and its preparation, can solve the problems of improving the stability of the formulation design preparation, the difficulty in establishing quality inspection indicators and methods, and the poor molding effect of the Yinzhihuang microcapsule preparation. It is ideal, the mechanism of exerting the curative effect is not very clear, etc., to achieve the effect of good microencapsulation effect, good medication compliance, good dispersion and stability

Pending Publication Date: 2020-07-17
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Existing studies on TCM microcapsules mainly focus on TCM monomer compounds, and there are few researches on single TCM active ingredient extracts and TCM compound prescriptions with relatively complex components.
The active ingredients of traditional Chinese medicine compound are complex and diverse, and the mechanism of exerting curative effect is not clear, so there are great difficulties in the selection of capsule materials, prescription design, improvement of preparation stability, quality inspection indicators and method establishment, etc.
In the preparation process of Yinzhihuang microcapsules, the inventors tried to prepare Yinzhihuang microcapsules by referring to the existing microcapsule preparation process, but due to the difference in the composition of the prescription and the difference in the preparation process of traditional Chinese medicine extracts, Yinzhihuang microcapsules Preparation molding effect is not ideal

Method used

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  • Virgate wormwood herb-cape jasmine fruit-baical skullcap root microcapsule preparation and preparation method thereof
  • Virgate wormwood herb-cape jasmine fruit-baical skullcap root microcapsule preparation and preparation method thereof
  • Virgate wormwood herb-cape jasmine fruit-baical skullcap root microcapsule preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Example 1 Yinzhihuang Microcapsule Tablets

[0091] 1) Preparation of extract fine powder

[0092] Capillary Extract 25g Gardenia Extract 8g

[0093] Scutellaria baicalensis extract (calculated as baicalin) 70g Honeysuckle extract 10g

[0094] The above four kinds of raw material extracts are evenly mixed to make 113g of Yinzhihuang extract fine powder, and set aside;

[0095] 2) Preparation process

[0096] A. Yinzhihuang extract fine powder: 113g

[0097] B. Gum Arabic: 625.5g

[0098] Soy protein isolate: 208.5g

[0099] C. Octadecanol: 15g

[0100] D. Citric acid: 38g

[0101] Add the capsule material, anti-adhesive agent and plasticizer of the above formula amount into purified water, heat and stir at 54°C to dissolve, configure a capsule material solution with a mass fraction of 28%, cool to room temperature, and add the formula amount under stirring The fine powder of Yinzhihuang extract and Tween80 8g were homogeneously emulsified to obtain an emulsion, wh...

Embodiment 2

[0103] Example 2 Yinzhihuang Microcapsule Capsules

[0104] 1) Preparation of extract fine powder

[0105] Capillary Extract 15g Gardenia Extract 8g

[0106] Scutellaria baicalensis extract (calculated as baicalin) 50g Honeysuckle extract 10g

[0107] The above four kinds of raw material extracts are evenly mixed to make 83g of Yinzhihuang extract fine powder, and set aside;

[0108] 2) Preparation process

[0109] A. Yinzhihuang extract powder: 83g

[0110] B. Maltodextrin: 431g

[0111] Soy protein isolate: 431g

[0112] C. Glyceryl monostearate: 11g

[0113] D. Propylene glycol: 44g

[0114] Add the capsule material, anti-adhesive agent and plasticizer of the above formula amount into purified water, heat and stir at 51°C to dissolve, configure a capsule material solution with a mass fraction of 30%, cool to room temperature, and add the formula amount under stirring The fine powder of Yinzhihuang extract and 10g of lecithin were homogeneously emulsified to obtain a...

Embodiment 3

[0116] Example 3 Yinzhihuang Microcapsule Tablets

[0117] 1) Preparation of extract fine powder

[0118] Capillary Extract 19g Gardenia Extract 11g

[0119] Scutellaria baicalensis extract (calculated as baicalin) 62g Honeysuckle extract 12g

[0120] The above four kinds of raw material extracts are uniformly mixed to make 104g of Yinzhihuang extract fine powder, and set aside;

[0121] 2) Preparation process

[0122] A. Yinzhihuang extract fine powder: 104g

[0123] B. Maltodextrin: 524.5g

[0124] Soy protein isolate: 314.6g

[0125] C. Titanium dioxide: 21g

[0126] D. Polyethylene glycol 6000: 36g

[0127] Add the capsule material, anti-adhesive agent and plasticizer of the above formula into purified water, heat and stir at 49°C to dissolve, configure a capsule material solution with a mass fraction of 33%, cool to room temperature, and add the formula amount under stirring The fine powder of Yinzhihuang extract and soybean lecithin 9g were homogeneously emulsifi...

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations, and discloses a virgate wormwood herb-cape jasmine fruit-baical skullcap root microcapsule preparation and a preparation method thereof. The microcapsule preparation is prepared from virgate wormwood herb-cape jasmine fruit-baical skullcap root extract fine powder, a capsule material, an anti-sticking agent and a plasticizer, and the preparation method of the virgate wormwood herb-cape jasmine fruit-baical skullcap root microcapsule preparation comprises preparation of the virgate wormwood herb-cape jasmine fruit-baical skullcap root extract fine powder and preparation of microcapsules. The virgate wormwood herb-cape jasmine fruit-baical skullcap root microcapsules are spherical or quasi-spherical, has small hygroscopicity and good fluidity, and is not agglomerated easily; the obtained microcapsule preparation has obvious slow release effect and high bioavailability, is not influenced by gastrointestinal rhythm, and can exert a best effect of treating cough; and meanwhile, through embedment by using the capsule material, the inherent bad smell of the virgate wormwood herb-cape jasmine fruit-baical skullcap root preparation can be covered, the taste is improved, and compliance of medication of children is improved.

Description

technical field [0001] The invention relates to a Yinzhihuang microcapsule preparation and a preparation method thereof, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] CN1616012A discloses a traditional Chinese medicine composition, which is composed of capillary extract, gardenia extract, scutellaria baicalensis extract and honeysuckle extract. Acute, chronic hepatitis and severe hepatitis (type I) caused by evil internal accumulation can also be used for comprehensive treatment of other types of severe hepatitis. The name of the medicine of the present invention is Yinzhihuang Granules, and the approval number is Z20030028; or Yinzhihuang Tablets, and the approval number is Z20050121. Both medicines are Chinese patent medicines of Lunan Houpu Pharmaceutical Co., Ltd. CN1709436A discloses a Yinzhihuang buccal tablet and its preparation and detection method, CN1709437A discloses a kind of Yinzhihuang dispersible tablet an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61K9/50A61P1/16
CPCA61K36/282A61K36/744A61K36/539A61K36/355A61K9/5089A61K9/5052A61P1/16
Inventor 张贵民关永霞马健李蔚群
Owner LUNAN PHARMA GROUP CORPORATION
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