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A kind of sodium aescinate pharmaceutical composition and preparation method thereof

A escin sodium and the technology of aescin, applied in the pharmaceutical composition containing sodium aescin and its preparation field, can solve the problems such as insignificant anti-inflammatory effect

Active Publication Date: 2020-11-17
SHANDONG LUYE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the content disclosed in the patent specification, the content of aescin A and B obtained by the preparation method provided by this patent is 30-40%, the content of aescin B is 15-20%, and the content of aescin A and B is close to the quality standard lower limit, the anti-inflammatory effect may not be obvious

Method used

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  • A kind of sodium aescinate pharmaceutical composition and preparation method thereof
  • A kind of sodium aescinate pharmaceutical composition and preparation method thereof
  • A kind of sodium aescinate pharmaceutical composition and preparation method thereof

Examples

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Comparison scheme
Effect test

preparation example 1

[0040] Preparation Example 1: Preparation of Sodium Aescinate

[0041] 300kg of dried Sala seed powder is soaked in 8 times the volume of 50% ethanol for 12 hours, then extracted for 4 hours, and then 5 times of 50% ethanol is added, and the second extraction is 5 hours. The third extraction conditions are the same as the second extraction, and the three extractions are combined liquid and filtered to obtain the final extract, wherein the temperature of immersion and extraction is controlled at 25°C;

[0042] Adjust the pH of the extract to 2.3 and add it to a D101 macroporous resin chromatography column, wash with 30% ethanol at a flow rate of 1.0BV / h for 2.7 times the volume of the resin, discard it, then wash with 95% ethanol at a flow rate of 0.6-0.65BV / h Remove 2.7 times the volume of the resin, and collect the eluate;

[0043] After adjusting the pH of the eluent to 5.3, take a sample to measure the quality of aescin ABCD in the eluent, add anhydrous ethanol and methano...

preparation example 2

[0049] Preparation Example 2: Preparation of Sodium Aescinate

[0050] 300kg of dried Sala seed powder is soaked in 8 times the volume of 50% ethanol for 12 hours, then extracted for 4 hours once, then added 7 times of 50% ethanol, and extracted for 5 hours twice. The conditions of the third extraction are the same as the second extraction, and the three extractions are combined liquid and filtered to obtain the final extract, wherein the soaking and extraction temperature is controlled at 30°C;

[0051] Adjust the pH of the extract to 2.5, then add it to a D101 macroporous resin chromatography column, wash with 30% ethanol at a flow rate of 0.9BV / h for 3 times the volume of the resin, discard it, and wash with 95% ethanol at a flow rate of 0.6-0.65BV / h Remove 3 times the resin volume and collect the eluate;

[0052] After adjusting the pH of the eluent to 5.5, take a sample to measure the quality of aescin ABCD in the eluent, add anhydrous ethanol and methanol in turn and co...

preparation example 3

[0058] Preparation Example 3: Preparation of Sodium Aescinate

[0059] 300kg of dried Sala seed powder is soaked in 8 times the volume of 50% ethanol for 12 hours, then extracted for 4 hours, and then 5 times of 50% ethanol is added, and the second extraction is 5 hours. The third extraction conditions are the same as the second extraction, and the three extractions are combined liquid and filtered to obtain the final extract, wherein the soaking and extraction temperature is controlled at 30°C;

[0060] Adjust the pH of the extract to 2.7 and add it to a D101 macroporous resin chromatography column, wash with 30% ethanol at a flow rate of 0.8BV / h for 3.3 times the volume of the resin, discard it, then wash with 95% ethanol at a flow rate of 0.6-0.65BV / h Remove 3.3 times the volume of the resin, and collect the eluate;

[0061] After adjusting the pH of the eluent to 5.7, take a sample to measure the quality of aescin ABCD in the eluent, add absolute ethanol and methanol in t...

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Abstract

The present invention relates to a medicinal composition containing sodium aescinate and a preparation method of the medicinal composition. The provided medicinal composition containing sodium aescinate is suitable in content ratio, good in medicinal effect, low in toxicity and low in irritation. The sum of the content of sodium aescinate A and sodium aescinate in the sodium aescinate medicinal composition is 55%-70%.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition containing sodium aescinate and a preparation method thereof. Background technique [0002] Aescin is the fruit extract of Aesculus aesculus or Aesculus hippocastanum L. It mainly contains four main components of aescin A, B, C, and D. It has anti-inflammatory, anti-exudation, increased venous tension, and improves blood circulation. Circulation and correction of brain dysfunction. [0003] Existing studies have found that different origins, different years, and different picking times will affect the content of aescin. Investigating the different origins of Sala seeds, it was found that the contents of aescin A and aescin B were significantly different [Determination of β-aescin content in Sala seeds from different origins by high performance liquid chromatography. Bian Jingjing. Chinese Medicinal Materials. Volume 35 ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704C07H15/256C07J63/00C07H1/08A61P7/10A61P9/00A61P29/00
CPCA61K31/704A61P7/10A61P9/00A61P29/00C07H1/08C07H15/256C07J63/00A61K2300/00
Inventor 范艳丽都平孟莹衣瑞玲郭俊冷晓燕许胜民
Owner SHANDONG LUYE PHARMA CO LTD