RNA binding protein recognition method based on multi-view depth features and multi-label learning

Abstract

The invention belongs to the field of intelligent cell biological recognition, and relates to an RNA binding protein recognition method based on multi-view depth features and multi-label learning. Themethod comprises a training stage and a use stage, wherein the training stage comprises initial multi-view data construction, a depth multi-view feature extraction model and multi-label classifier training, wherein the initial multi-view data construction comprises the following steps: converting an original RNA sequence into an amino acid sequence and a dipeptide component by using a molecular biology principle and a statistics principle to obtain the characteristics of the amino acid sequence and the dipeptide component, and then constructing an initial multi-view characteristic together with the original RNA sequence, and constructing a model for the initial multi-view characteristic. According to the method, based on the initial multi-view data, the CNN is used for deep learning to construct a deep multi-view characteristic, and compared with the original multi-view characteristic, the multi-view characteristic extracted based on the deep features have smaller data dimensions anda higher classification effect.

Description

technical field

[0001] The invention belongs to the field of intelligent cell biological recognition, and relates to an RNA-binding protein recognition based on multi-view depth features and multi-label learning. Background technique

[0002] RNA, the full name of ribonucleic acid, exists in biological cells and the genetic information carriers in some viruses and virus-like viruses. In living organisms, it mainly plays a role in regulating the expression of coding genes, and also serves as a template for synthesizing proteins after gene transcription. It is an indispensable ingredient in life. If an RNA wants to perform its function smoothly, it generally needs to be mediated by RNA binding protein (RBP), so the lack of a certain RBP may cause a certain type of RNA to be unable to perform its regulatory or translation functions, thus making the living body lack some important functions. Abnormal proliferation of proteins or certain proteins, affecting their own functions. ...

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