Microneedle drug release device and manufacturing method, skin disease treatment device

Abstract

The invention discloses a manufacturing method related to the field of biomedicine, especially a microneedle drug release device, comprising the following steps: A, making a drug release device from a therapeutic drug and a drug-loaded substance by a double emulsification method; making a microneedle system carrier material; B. 1. Add the drug release device into the microneedle template, and then fill the microneedle template with the carrier material of the microneedle system; C. Take it out after drying to obtain the microneedle drug release device. By adding a photothermal conversion agent to the drug-loaded particles, the drug-release device can absorb light of a specific wavelength, and the drug-loaded particles containing therapeutic drugs are delivered to the diseased tissue, and the drug-loaded particles are released. When irradiated with light, the drug-loaded particles The photothermal conversion agent in the drug particles converts light energy into heat energy, which can not only make the diseased tissue hyperthermic to kill the lesion, but also control the release behavior of the therapeutic drug in the drug-loaded particles, so as to achieve the goal of synergistic treatment between chemotherapy and photothermal therapy.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a microneedle medicine release device, a manufacturing method, and a skin disease treatment device. Background technique [0002] Epidermal diseases include microbial infection, cancer, and injury. Taking epidermal cancer as an example, epidermal cancer is a malignant skin tumor. With the aging of the population in my country, its incidence rate is gradually increasing. According to the source of tumor cells, epidermal malignancies can be divided into squamous cell carcinoma, basal cell carcinoma, and malignant melanoma. Epidermal malignancies are superficial and are usually treated with surgical excision, radiation therapy, chemotherapy, and laser therapy. Surgical therapy may not be able to completely remove the remaining tumor cells, which can easily lead to tumor recurrence. Radiotherapy and chemotherapy will have a certain therapeutic effect, but they will produce serious side e...

AI Technical Summary

Problems solved by technology

Although microneedle administration has many advantages, it is difficult to control the speed of drug release, and it is also impossible to control the temperature at which the microneedle penetrates into the lesion.

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