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Lobetyolin-loaded pullulan nano microsphere for treating spinal cord injury

A technology of pullulan polysaccharide and Codonopsis glucoside, applied in the field of medical materials, can solve the problems of no surgery, secondary spinal cord injury, etc., and achieve the effects of ensuring activity, improving biocompatibility, and promoting myelin regeneration.

Inactive Publication Date: 2020-08-21
NANTONG UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a pullulan nano-microsphere loaded with stangoside for the treatment of spinal cord injury and its preparation method, which solves the problem that there is no effective surgical operation and medicine to treat the secondary injury of the spinal cord. question

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  • Lobetyolin-loaded pullulan nano microsphere for treating spinal cord injury
  • Lobetyolin-loaded pullulan nano microsphere for treating spinal cord injury
  • Lobetyolin-loaded pullulan nano microsphere for treating spinal cord injury

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Embodiment Construction

[0035] In order to make the technical problems, technical solutions and advantages to be solved by the present invention clearer, the following will describe in detail with reference to the drawings and specific embodiments.

[0036] The invention provides a pullulan nano-microsphere loaded with tangoside for the treatment of spinal cord injury, comprising the following components: 1-20 mL of 4% Span-80 paraffin oil, 0.1-5 mL of 5% pullulan physiological balance solution, Codonopsis 1~20mg and 8% polyethylene glycol 6000 solution 10~100μL.

[0037] Preferably, the pullulan nanospheres loaded with tangshenoside for the treatment of spinal cord injury include the following components: 10 mL of 4% Span-80 paraffin oil, 1 mL of 5% pullulan physiological balance solution, and 10 mg of tangshenoside and 50 μL of 8% polyethylene glycol 6000 solution.

[0038] The present invention also provides a preparation method of pullulan nano-microspheres loaded with tangshenoside for the trea...

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Abstract

The invention provides a lobetyolin-loaded pullulan nano microsphere for treating spinal cord injury and a preparation method of the lobetyolin-loaded pullulan nano microsphere. The nano-microsphere comprises the following components: 1 to 20 mL of 4% Span-80 paraffin oil, 0.1 to 5 mL of 5% pullulan physiological equilibrium liquid, 1 to 20 mg of lobetyolin and 10 to 100 [mu] L of 8% polyethyleneglycol 6000 solution. According to the invention, a very powerful theoretical basis is provided for repair after acute spinal cord injury; lobetyolin is prepared into the biological nano material, long-term slow release can be provided for lobetyolin, meanwhile, the activity of lobetyolin is guaranteed to the maximum extent, and the problems that no effective surgical operation exists at present and drugs can treat spinal cord secondary injuries are solved.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a pullulan nano-microsphere loaded with tangshenoside for treating spinal cord injury and a preparation method thereof. Background technique [0002] The technique of preparing microspheres from polymers has been widely used in controlled protein drug delivery systems. Studies have found that microspheres can protect lipid drugs, increase their stability, avoid oxidation during administration, increase their water solubility, improve bioavailability, prolong the release time of lipid drugs, and protect their lipids. activity, thereby increasing the efficacy and reducing the toxicity of metabolites to the kidneys. [0003] Polysaccharides from natural sources have good biological properties, high stability, good biocompatibility, biodegradability, etc., as well as good physical and chemical properties, including high reactivity, pH sensitivity, etc. It exists widely in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/06A61K47/36A61K47/10A61K31/7032A61P25/00
CPCA61K9/5123A61K9/5146A61K9/5161A61K31/7032A61P25/00
Inventor 王成牛徐大伟
Owner NANTONG UNIVERSITY
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