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Devices and methods for delivering therapeutics

A therapeutic agent and pancreas technology, applied in the direction of biochemical equipment and methods, pharmaceutical equipment, microorganisms, etc., can solve bulky and bulky problems

Pending Publication Date: 2020-08-21
SEMMA THERAPEUTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therapeutic devices supporting automated delivery of insulin can be bulky and cumbersome for patient use

Method used

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  • Devices and methods for delivering therapeutics
  • Devices and methods for delivering therapeutics
  • Devices and methods for delivering therapeutics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0167] Film manufacturing

[0168] This example describes the manufacture of membranes (eg, electrospun polymer membranes). The membrane preparation process is carried out using a climate-controlled electrospinning equipment (EC-CLI, IME Technologies), which consists of a single emitter with a 19-gauge needle and a rotating drum collector with a diameter of 6 cm running at 500 rpm, both The distance is between 5 and 17 cm. The polymer solution (6% w / v) was fed into the emitter through a 0.8 mm PTFE tube at a flow rate of 16.7 μL / min under 50% humidity and 23°C. The transmitter is set between 15kV and 18kV, and the collection drum is kept at -4kV. After satisfactory fiber formation, the x-axis translation stage of the transmitter was set to repeat a linear pattern with a speed of 100 mm / s and a delay of 200 ms at the edge. The total collection time after activating the translation stage is 140 min. Films (e.g., electrospun polymer films) can also be collected on the patterned ...

Embodiment 2

[0171] PAN film with different diameters

[0172] This example describes scanning electron microscopy and the cumulative release of proteins from PAN membranes with different diameters (eg, electrospun polymer membranes). A film (for example, an electrospun polymer film) was manufactured according to Example 1. A 6% (w / v) PAN polymer solution was used to electrospin the PAN polymer. The diameter of the filaments in the resulting electrospun polymer film is changed by controlling the polymer concentration and voltage. Table 1 shows the electrospinning parameters, including polymer solution concentration (w / v), positive and negative voltage settings (kV), feed rate, distance and electrospinning time. These electrospinning parameters are used to obtain 540nm, 325nm and A 50μm thick polymer film of 202nm diameter fibrous filaments.

[0173] Table 1 Polyelectrospinning parameters

[0174]

[0175] The electrospun polymer film was spun to a thickness of 50 μm. The electrospun membrane...

Embodiment 3

[0179] Protein release from PAN electrospun polymer membrane

[0180] This example describes the release of proteins of different molecular weights from PAN electrospun polymer membranes. According to Example 1, an electrospun polymer film was manufactured. PAN polymer is electrospun with 6% (w / v) polymer solution. The release study was performed as described in Example 2 above.

[0181] Figure 2 shows the diffusion of 4kDa FITC-dextran molecules and 500kDa FITC-dextran molecules from a base polymer blend that is electrospun to produce 540nm filament diameter or 202nm filament diameter . Figure 2A Shows the diffusion of 4kDa FITC-dextran molecules and 500kDa FITC-dextran molecules from a base polymer blend at 30min and 60min, which is electrospun into filaments with a diameter of 540nm 100 micron thick film. Figure 2B Shows the diffusion of 4kDa FITC-dextran molecules and 500kDa X moieties from a base polymer blend at 30min and 60min, which is electrospun into a 100-micron thi...

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Abstract

Disclosed herein are devices, methods, and compositions for delivering a therapeutic, e.g., a cell or a therapeutic agent. Disclosed is a device comprising a membrane and a population of non-native pancreatic beta cells, wherein said non-native pancreatic beta cells exhibit an in vitro glucose-stimulated insulin secretion (GSIS) response to a glucose challenge. Disclosed is a method of treating acondition comprising: placing a device disclosed herein in a subject in need thereof In some cases, said device is configured to remain in said subject for a period of more than six months, said condition is a chronic disease. In some cases, said chronic disease is diabetes.

Description

[0001] cross reference [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 519,702 filed on June 14, 2017, which is incorporated herein by reference in its entirety. Background technique [0003] Diabetes is a chronic disease that affects the quality of life of patients. Therapeutic devices that support the automatic delivery of insulin can be bulky and cumbersome for patient use. Implantable devices can provide the advantages of caution and ease of management. Implantable devices can benefit from exhibiting long-term structural integrity, and can benefit from allowing the passage of therapeutics without allowing the penetration of host proteins. The present invention provides a device and a method of administering the device, which allow high throughput of low molecular weight therapeutic moieties while restricting the passage of larger proteins or cells. Summary of the invention [0004] Disclosed herein are devices, methods, and compositions for...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/70A61K45/06A61K38/26A61K38/28A61K38/31A61K35/39A61K47/32A61K47/34A61P3/10
CPCA61K35/39C12N5/0676C12N2537/10A61K38/18A61K38/43A61K9/0024A61K9/7007A61F2/022A61L27/54A61L27/56A61L27/3804A61L27/3834A61L2400/12A61L2300/252A61L2300/43A61K9/00C12N5/0678A61M31/002C12N5/0613
Inventor 克里斯多佛·萨诺斯邱阳
Owner SEMMA THERAPEUTICS INC
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