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A kind of preparation method of gamma-pga nanofiber

A technology of nanofibers and hyperbranched polyamides, which is applied in the field of preparation of γ-PGA nanofibers, can solve the problems of small draw ratio, low yield, high frictional resistance, etc., achieve improved water stability, broad application space, Prolonged effect

Active Publication Date: 2022-05-31
ZETTA NANO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the large frictional resistance of the liquid coagulation bath, the drawing rate is relatively low, the drawing ratio is also small, and the yield is low, the diameter of the fiber obtained by air-jet spinning often cannot meet the demand

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

Embodiment 2

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Abstract

The invention provides a method for preparing γ-PGA nanofibers. The fibers are prepared by jet spinning, and the modified γ-PGA nanofibers are fully water-stabilized and modified. Before the spinning jet stream enters the coagulation bath It needs to pass through an air section, and the fibers are fully cross-linked and the diameter meets the requirements, ensuring that the obtained γ-PGA nanofibers have both water stability and good applicability.

Description

A kind of preparation method of γ-PGA nanofiber technical field The invention belongs to nanofiber field, particularly a kind of preparation method of γ-PGA nanofiber. Background technique [0002] γ-polyglutamic acid (γ-PGA) is a natural polymer material synthesized by microorganisms. In mammals, γ-PGA can be degraded to harmless glutamate by γ-polyglutamate transpeptidase. Numerous studies have shown that γ-PGA is a It is a polymer material with good biodegradability, biocompatibility, and non-toxicity to humans and the environment. In the field of medicine, γ‑ PGA can achieve sustained release of drugs, improve drug water solubility, reduce adverse drug reactions, and improve drug efficacy. After being spun into fiber, γ-PGA can be widely used in the field of biomedicine, and independent γ-PGA fiber is easy to be used. It is degraded in water and has poor water stability, which limits some applications. In the prior art, γ-PGA is usually chemically modified. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F6/90D01F1/10D01D5/04D01D5/06
CPCD01F6/90D01F1/10D01D5/04D01D5/06Y02P20/10
Inventor 徐正东
Owner ZETTA NANO TECH CO LTD