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Bacteriostatic, anti-inflammatory and itching-relieving composition and preparation method thereof

A composition and biofilm technology, applied in the directions of drug combinations, antibacterial drugs, pharmaceutical formulations, etc., can solve the problems of unsatisfactory antipruritic effect, inconvenient application, strong odor, etc., and achieve the relief of skin itching, the safety of ingredients, and the degree of acceptance. high effect

Active Publication Date: 2020-09-22
中科宸星杭州科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Commonly used topical skin antipruritic topical formulations contain a variety of chemical ingredients, which generally have the disadvantages of strong odor, inconvenient application, and unsatisfactory antipruritic effect. The smell of some products can also make people feel unpleasant.

Method used

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  • Bacteriostatic, anti-inflammatory and itching-relieving composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～7

[0027] Examples 1-7 provide an antibacterial, anti-inflammatory, and antipruritic composition, the composition of which is shown in Table 1.

[0028] The preparation method of the antibacterial, anti-inflammatory, antipruritic composition of Examples 1-7 is:

[0029] (1) Take glyceryl caprylate, caprylyl hydroxamic acid, p-hydroxyacetophenone and ethanol, mix, add appropriate amount of water to dissolve;

[0030] (2) Heat the remaining water to 85°C, keep the temperature constant for 30 minutes (or keep the temperature at 80-90°C for 20-40 minutes), then add dipotassium glycyrrhizinate and disodium EDTA to dissolve;

[0031] (3) Cool the solution obtained in step (2) to 45°C (40-45°C is acceptable) at a rate of 0.6°C / min (0.2-0.6°C / min is acceptable), and then add the solution obtained in step (1) , stir evenly, then add N-acetylneuraminic acid and honeysuckle extract, stir evenly, and filter with a sterile membrane to obtain the antibacterial, anti-inflammatory and antipruri...

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PUM

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Abstract

The invention discloses a bacteriostatic, anti-inflammatory and itching-relieving composition. The composition disclosed by the contains N-acetylneuraminic acid and a honeysuckle flower extract, has very good repairing, inflammation diminishing and anti-allergy effects, can effectively relieve skin itch caused by mosquito bites, and can quickly eliminate phenomena such as skin redness and swellingcaused by mosquito bites. The composition disclosed by the invention is a homogeneous liquid preparation, is good in stability, free of essence and pungent smell, high in consumer acceptance degree,convenient to use, cool and comfortable in use feeling, free of clothes pollution, safe in component, suitable for all people, simple in preparation process and beneficial to quantitative production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to an antibacterial, anti-inflammatory and antipruritic composition and a preparation method thereof. Background technique [0002] As the climate warms up, mosquitoes breed in large numbers, and the chances of people being bitten by mosquitoes increase significantly. When a mosquito bites the human body, the saliva in its salivary glands will inject into the human skin. Mosquito saliva contains a variety of anticoagulant chemical substances, which cause petechiae and ecchymosis on the bitten human skin; at the same time, mosquito saliva contains allergy-related proteins such as salivary allergens, natural antigen proteins, and adenosine deaminase , These substances cause local or systemic allergic reactions in the human body after being bitten. This type of dermatitis caused by mosquito bites is called insect bite dermatitis and is a common conditi...

Claims

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Application Information

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IPC IPC(8): A61K36/355A61K47/10A61K47/14A61K47/18A61K47/28A61P17/02A61P17/04A61P31/02A61P31/04A61P37/08A61K31/351
CPCA61K36/355A61K31/351A61K47/14A61K47/10A61K47/28A61K47/183A61K47/18A61P17/02A61P17/04A61P31/02A61P37/08A61P31/04A61K2300/00
Inventor 袁丽霞陈祥松吴金勇孙立洁姚建铭王纪
Owner 中科宸星杭州科技有限公司
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