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Flexible implantable fibrous organic electrochemical transistor and preparation method thereof

A fibrous and transistor technology, applied in the field of fibrous organic electrochemical transistors and their preparation, can solve problems such as difficulty in adapting to rapid changes, achieve excellent biocompatibility, reveal physiological mechanisms, and assist in disease diagnosis and treatment.

Active Publication Date: 2020-09-22
FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The classic microdialysis combined with high performance liquid chromatography has high sensitivity, but the time resolution of detection is on the order of minutes, which is difficult to adapt to the rapid changes of chemical substances in the biological body in seconds or even milliseconds

Method used

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  • Flexible implantable fibrous organic electrochemical transistor and preparation method thereof
  • Flexible implantable fibrous organic electrochemical transistor and preparation method thereof
  • Flexible implantable fibrous organic electrochemical transistor and preparation method thereof

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Embodiment Construction

[0024] Below in conjunction with specific implementation case, exemplary explanation and help further understanding of the present invention, but the specific details of implementation case are only for illustrating the present invention, do not represent all technical solutions under the present invention concept, therefore should not be interpreted as the overall technical scheme of the present invention The limitation of the technical solution, some insubstantial additions and changes that do not deviate from the concept of the present invention in the eyes of a skilled person, such as simple replacement or replacement of technical features with the same or similar technical effects, all belong to the protection scope of the present invention.

[0025] The source and drain electrodes and channel of the fibrous organic electrochemical transistor are prepared. The nylon wire with a diameter of 50 μm was used as the substrate, and after the middle section was physically masked ...

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Abstract

The invention belongs to the technical field of bioelectrochemical detection, and particularly relates to a flexible implantable fibrous organic electrochemical transistor and a preparation method thereof. A transistor source-drain electrode and a channel are prepared by taking a flexible polymer fiber as a substrate, and a transistor grid is prepared by taking a carbon nanotube fiber as a substrate and modifying an active substance; and the two are twisted by a twisting process to finally obtain the integrated fibrous organic electrochemical transistor. The flexible implantable fibrous organic electrochemical transistor can amplify a detection signal in situ in real time; stable detection of tiny concentration changes of chemical substances in various organisms is realized; the flexible implantable fibrous organic electrochemical transistor has the properties of high sensitivity, wide detection window, high stability and the like, can be implanted into deep tissue through minimally invasive surgery, is proved by histology and animal experiments to have excellent biocompatibility, and provides a new means for exploring biological basic physiological functions, uncovering a secret physiological mechanism and assisting in disease diagnosis and treatment.

Description

technical field [0001] The invention belongs to the technical field of bioelectrochemical detection, and in particular relates to a fibrous organic electrochemical transistor and a preparation method thereof. Background technique [0002] The dynamic balance of chemical substances in living organisms is of great significance for maintaining physiological activities and functions. Abnormal fluctuations in the concentration of chemical substances are closely related to diseases. Therefore, monitoring the changes in the concentration of these substances can help to understand the function of the body, assist in the treatment of diseases, and prevent the occurrence of diseases. However, these chemical substances are often distributed in deep tissues, and the concentration is low and changes rapidly, making detection difficult. The classic microdialysis combined with high performance liquid chromatography has high sensitivity, but the detection time resolution is on the order of...

Claims

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Application Information

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IPC IPC(8): G01N27/414B82Y40/00B82Y15/00
CPCG01N27/4145G01N27/4146B82Y15/00B82Y40/00Y02E10/549
Inventor 彭慧胜孙雪梅吴晓颖冯建友
Owner FUDAN UNIV
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