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Immunohistochemical PD-L1 membrane staining pathological section image processing method, device and equipment

A PD-L1, immunohistochemical technology, applied in image data processing, image enhancement, image analysis, etc., can solve the problem of pathologist time-consuming, difficult and suspicious tissue area identification and other problems, and achieve good interpretability.

Active Publication Date: 2020-09-22
杭州迪英加科技有限公司 +1
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Problems solved by technology

[0004] However, for the analysis of immunohistochemical PD-L1 (SP263) membrane stained section images, there are many challenges that make the work of pathologists difficult and time-consuming. Efficiently and accurately identify suspicious tissue areas

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  • Immunohistochemical PD-L1 membrane staining pathological section image processing method, device and equipment
  • Immunohistochemical PD-L1 membrane staining pathological section image processing method, device and equipment
  • Immunohistochemical PD-L1 membrane staining pathological section image processing method, device and equipment

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Embodiment Construction

[0032] Hereinafter, exemplary embodiments of the present application will be described in detail with reference to the accompanying drawings. Apparently, the described embodiments are only some of the embodiments of the present application, rather than all the embodiments of the present application. It should be understood that the present application is not limited by the exemplary embodiments described here.

[0033] Application overview

[0034] Currently, the immunohistochemical method for PD-L1 (SP263) membrane staining section analysis is as follows:

[0035] 1) Divide the slice into four partitions, and interpret and count the tumor cells in each partition;

[0036] 2) Interpret the positive tumor cells and negative tumor cells in each partition, in which the linear brown cell membrane staining (partial or complete) of the positive tumor cells can be seen, and the cell membrane of the negative tumor cells has no staining, only the cytoplasm staining;

[0037] 3) Any i...

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Abstract

The invention relates to an immunohistochemical PD-L1 membrane staining pathological section image processing method, device and equipment. The image processing method comprises the following steps: acquiring a digital section full-field image of a to-be-diagnosed immunohistochemical PD-L1 (SP263) membrane staining pathological section; adopting a region segmentation network to identify and segment a tumor cell region in the digital slice full-field image under the first visual field multiplying power to obtain a tumor cell region probability graph of the whole digital slice full-field image;identifying and segmenting cells in each digital slice full-field graph, taking the tumor cell region probability graph as a weight matrix to carry out region constraint on the cell positioning network, identifying cell characteristics on the digital slice full-field graph, and positioning and classifying various cells on the digital slice full-field graph; and marking the cell position, the celltype and the immunohistochemical PD-L1 (SP263) index on the full-field diagram of the digital slice. By designing a multi-level feature collaborative diagnosis strategy, the tumor proportion score isaccurately evaluated in a mode of constraining cell features by using regional features.

Description

technical field [0001] The present invention relates to the field of pathological image processing, in particular to an immunohistochemical PD-L1 membrane staining pathological section image processing method, device, equipment and computer-readable storage medium. Background technique [0002] With the development of pathological diagnostic technology and molecular biomedicine in recent years, the Department of Pathology has shown an unprecedented development momentum. Currently, pathological diagnosis is the gold standard for tumor diagnosis. Pathologists provide evidence for the final diagnosis by analyzing pathological slides, making pathological diagnosis an indispensable part of tumor treatment. As a key technology of histopathology or cytopathology, immunohistochemistry technology is one of the key technologies in the current process of tumor interpretation, diagnosis and treatment, and has great influence. [0003] The so-called immunohistochemical technique or immu...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06T7/00G06T7/11G06T3/40G06N3/04G06N3/08
CPCG06T7/0012G06T7/11G06T3/4038G06N3/08G06T2207/30024G06T2207/30096G06T2207/20221G06T2207/20081G06T2207/20084G06N3/045
Inventor 杨林亢宇鑫李涵生崔磊费达付士军徐黎杨海英
Owner 杭州迪英加科技有限公司
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