Chiral resolution device for racemic epoxy chloropropane

Abstract

The invention discloses a chiral resolution device for racemic epoxy chloropropane. The device comprises a resolution kettle and a first jacket, wherein the first jacket sleeves the resolution kettle;a first stirring paddle is arranged in the resolution kettle; when utilizing high vacuum, the steam pressure difference is caused by the temperature difference between a distillation still and a collecting tank so that the chiral epoxy chloropropane can be distilled out under the condition of very low temperature, and therefore, in the process of distilling the chiral epoxy chloropropane, denaturation or loss of a catalyst cannot be caused; the chiral epoxy chloropropane layer does not contain water so that ring opening of chiral epoxy chloropropane is avoided during distillation, the yield is not influenced, and distilled hot water can be applied to distillation heating of chiral epoxy chloropropane, energy is saved, after water distillation and fractionation, remaining chiral chloro propanediol can be purified without the need of distillation, and generation of polymer impurities caused by too high distillation temperature is avoided.

Description

technical field [0001] The invention belongs to the technical field related to chemical production, and in particular relates to a chiral resolution device for racemic epichlorohydrin. Background technique [0002] Epichlorohydrin is composed of S-epichlorohydrin and R-epichlorohydrin each accounting for 50%, of which S-epichlorohydrin is used as a variety of chiral pharmaceutical intermediates, such as L-carnitine, atorvastatin etc., its importance is self-evident. [0003] Since racemic epichlorohydrin is cheap and easy to obtain, obtaining chiral epichlorohydrin through kinetic resolution has become the main method for preparing its chiral compounds. Its reaction equation is as follows: [0004] [0005] In 1997, Jacobsen's group reported the hydrolysis kinetic resolution of racemic epichlorohydrin using a homogeneous salen Co(Ⅲ)(OAc) catalyst. According to the Chinese patent application number 200910061164.4, a method for preparing an atorvastatin intermediate (R)-...

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Problems solved by technology

[0007] The object of the present invention is to provide racemic epichlorohydrin chiral resolution device, to solve the above-mentioned background technology when carrying out vacuum distillation chiral epichlorohydrin, because there is also a small amount of water and a large amount of catalyst in the system, Can cause the target product——chiral epichlorohydrin to continue to be hydrolyzed into chloroglycerin, which leads to a decline in yield, and because the chloroglycerin of the opposite configuration is obtained, the E.E value of the chirality of chloroglycerin is also reduced, affecting Its use value and homogeneous chiral catalyst are difficult to recover through this process. On the one hand, it causes a waste of valuable chiral catalyst. On the other hand, because it is mixed with the polymer, the catalyst not only cannot be recovered, but also Become a part of solid waste, which greatly increases the cost of production

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