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Application of sodium p-hydroxybenzoate in preparation of medicine for treating or preventing inflammatory bowel diseases

A technology for sodium hydroxybenzoate and inflammatory bowel disease, which is applied in the application field of sodium p-hydroxybenzoate in the preparation of medicines for treating or preventing inflammatory bowel disease, and can solve problems such as liver side effects and the like

Inactive Publication Date: 2020-10-30
GUILIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The inventor found in previous experiments that p-hydroxybenzoic acid could effectively relieve the symptoms of enteritis model mice induced by dextran sodium sulfate (DSS) at a dose lower than that of mesalamine, but found in follow-up studies that gavage When p-hydroxybenzoic acid is given to model mice, although it can significantly alleviate the symptoms of UC, it will cause side effects on the liver

Method used

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  • Application of sodium p-hydroxybenzoate in preparation of medicine for treating or preventing inflammatory bowel diseases
  • Application of sodium p-hydroxybenzoate in preparation of medicine for treating or preventing inflammatory bowel diseases
  • Application of sodium p-hydroxybenzoate in preparation of medicine for treating or preventing inflammatory bowel diseases

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Embodiment Construction

[0021] The technical solution of the present invention will be further described below in conjunction with specific embodiments.

[0022] In animal experiments, 2.5% dextran sulfate sodium (DSS) solution was used to induce C57BL / 6 mice to construct UC models, and the model mice were administered intragastrically with sodium p-hydroxybenzoate, p-hydroxybenzoic acid and the positive drug mesalamine, The improvement effect of sodium p-hydroxybenzoate on UC was analyzed.

[0023] 1. Materials

[0024] 1.1 Experimental animals

[0025] SPF grade C57BL / 6 mice, female, 6-8 weeks old, weighing 20±2g, purchased from Hunan Slake Jingda Experimental Animal Co., Ltd., license number: SCXK (Xiang) 2016-0002, certificate number: SYXK (Gui) 2013-0001. They were raised in an environment with a temperature of 25±2°C and a relative humidity of 55±10%, with free access to food and water. Use after one week of adaptation.

[0026] 1.2 Experimental reagents

[0027] Sodium p-hydroxybenzoate;...

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Abstract

The invention discloses application of sodium p-hydroxybenzoate in preparation of a medicine for treating or preventing inflammatory bowel diseases. Under the condition that the dosage is obviously lower than that of mesalazine, sodium p-hydroxybenzoate can obviously inhibit the increase of the disease activity index score of enteritis model mice induced by dextran sodium sulfate, improve the contraction in length of colons of colitis model mice, reduce the MPO activity of the colons of the mice, and relieve inflammatory cell infiltration of colons of the colitis model. The invention also discloses a medicine for treating or preventing inflammatory bowel diseases. Sodium p-hydroxybenzoate is used as an effective component of the medicine and the medicine contains an effective dose of sodium p-hydroxybenzoate in treatment.

Description

technical field [0001] The invention relates to the application of sodium p-hydroxybenzoate, in particular to the application of sodium p-hydroxybenzoate in the preparation of medicines for treating or preventing inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease that mainly involves the ileum, rectum, and colon. The clinical manifestations are diarrhea, abdominal pain, and even bloody stool. Inflammatory bowel diseases include ulcerative colitis (UC) and Crohn's disease (CD). Ulcerative colitis is a continuous inflammation of the colonic mucosa and submucosa. The disease usually involves the rectum first and gradually spreads to the entire colon. Crohn's disease is a discontinuous full-thickness inflammation that can involve the entire digestive tract. Terminal ileum, colon and perianal area. As a typical inflammatory bowel disease, UC occurs in young adults aged 30-40, and there is n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61P1/00A61P1/04A61P29/00
CPCA61K31/192A61P1/00A61P1/04A61P29/00
Inventor 王宇晖段小群徐笑天郑董璇张溪杨魏承琼
Owner GUILIN MEDICAL UNIVERSITY
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