Application of melatonin composition in preparation of weight-reducing and lipid-lowering drug

A technology of melatonin and composition, applied in the application field of melatonin composition in the preparation of weight loss and lipid-lowering drugs, to achieve the effect of inhibiting the level of quinated protein, reducing body weight and abdominal fat weight, and reducing weight gain

Inactive Publication Date: 2020-10-30
上海百山生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the application of EGCG combined wit

Method used

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  • Application of melatonin composition in preparation of weight-reducing and lipid-lowering drug
  • Application of melatonin composition in preparation of weight-reducing and lipid-lowering drug
  • Application of melatonin composition in preparation of weight-reducing and lipid-lowering drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～6

[0030] Embodiment 1~6, a kind of melatonin composition

[0031] Melatonin composition formula, as shown in table 1:

[0032] group EGCG melatonin Stachyose Example 1 3.0mg / mL 0.2mg / mL 0.16mg / mL Example 2 3.5mg / mL 0.3mg / mL 0.45mg / mL Example 3 4.0mg / mL 0.5mg / mL 0.5mg / mL Example 4 4.5mg / mL 0.6mg / mL 1.2mg / mL Example 5 3.5mg / mL 0.4mg / mL 0.6mg / mL Example 6 3.5mg / mL 0.4mg / mL /

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Abstract

The invention relates to the technical field of weight reduction and lipid reduction, in particular to an application of a melatonin composition in preparation of a weight-reducing and lipid-loweringdrug, the melatonin composition comprises melatonin and EGCG, and the mass ratio of the melatonin to the EGCG is (2-6): (30-45). According to the invention, the melatonin is combined with the EGCG foruse for the first time; the melatonin composition can reduce the body weight and abdominal fat weight of a mouse suffering from type 2 diabetes; the expression of fatty acid synthetase protein in abdominal fat of mice with type 2 diabetes mellitus and the expression of fatty acid synthetase protein in livers can be obviously inhibited; the melatonin composition can achieve the effects of reducingweight gain or losing weight and lowering lipid by inhibiting fat synthesis and reducing fat accumulation, stachyose is accidentally added, the quinonylation protein level can be remarkably inhibited, and the activity of EGCG can be improved.

Description

technical field [0001] The invention relates to the technical field of weight loss and lipid reduction, in particular to the application of a melatonin composition in the preparation of weight loss and lipid lowering drugs. Background technique [0002] Overnutrition and a long-term static lifestyle lead to overweight, obesity, and even type 2 diabetes. According to surveys by WHO and related agencies, as of 2014, the number of obese people in the world has exceeded 1.5 billion, and type 2 diabetes patients have exceeded 420 million; and it is predicted that by 2035, the number of global diabetic patients will exceed 600 million. Diabetes is a major global health problem. Except for HIV / AIDS, diabetes is the primary disease that reduces global health-adjusted life expectancy (HALE0). For a long time, reducing fat accumulation and thus controlling weight gain has been an effective means of preventing obesity and type 2 diabetes. [0003] Melatonin is secreted by the pineal ...

Claims

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Application Information

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IPC IPC(8): A61K31/4045A61K31/353A61K31/702A61P3/04A61P3/10
CPCA61K31/353A61K31/4045A61K31/702A61P3/04A61P3/10A61K2300/00
Inventor 赵广山
Owner 上海百山生物技术有限公司
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