Application of novel flavonoid compound Hyd

A technology of compounds and hydrates, applied in the field of medical use of flavonoids, to reduce hyperphosphorylation, realize waste utilization, and delay cardiomyocyte apoptosis

Active Publication Date: 2020-10-30
YANTAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In addition, there are still many rich active substances contained in seabuckthorn that have not been isolated and identified. If we can conduct more in-depth and subtle research on the new chemical

Method used

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  • Application of novel flavonoid compound Hyd
  • Application of novel flavonoid compound Hyd
  • Application of novel flavonoid compound Hyd

Examples

Experimental program
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Embodiment 1

[0050] The preparation of embodiment 1 new flavonoid compound

[0051] 1. Preparation of components

[0052] (1) 20.00kg of seabuckthorn (Hippophae rhamnoides Linn.) seed meal was extracted in 70% ethanol solution, the ratio of solid to liquid was 1:20kg / L, extracted for 2 hours each time, the temperature was 60°C, extracted 3 times, and the extracts were combined for 3 times Then concentrate under reduced pressure to obtain 3.50 kg of ethanol extract of seabuckthorn seed meal.

[0053] (2) Freeze-dry the alcohol extract, crush it through a 120-mesh sieve, add a small amount of methanol, mix it with 200-300-mesh normal-phase silica gel 1:1, and volatilize until there is no alcohol smell. Add 7kg 200~300 mesh normal phase silica gel in the glass chromatography column, use dichloromethane:methanol:water=7:3:0.5 to do mobile phase to carry out elution, elution volume is 20 column volumes, to eluent Concentrate under reduced pressure to obtain extract.

[0054](3) Dissolve the ...

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Abstract

The invention discloses an application of a novel flavonoid compound Hyd. A hippophae rhamnoides seed meal extract is eluted through an MCI gel column; semi-preparative separation is sequentially performed through a C18 chromatographic column, a diol chromatographic column and a C18 chromatographic column to obtain the novel flavonoid compound Hyd; the compound Hyd is subjected to activity research, it is verified that the compound Hyd can reduce the content of lactic dehydrogenase and NO in myocardial cells, apoptosis of the myocardial cells is delayed by reducing the protein expression levelof Bcl-2 and Bax in the cells, and the compound Hyd can be used for preparing medicine for preventing or treating myocardial injury related diseases. The invention also provides application of the new compound Hyd in preparation of products with neuroprotection and/or nerve repair effects, and verifies that the compound Hyd can improve neurosynaptic atrophy and reduce tau protein excessive phosphorylation, and can be used for preparing medicines for preventing or treating neurodegenerative diseases.

Description

technical field [0001] The present invention relates to the field of medical application of flavonoids, in particular to the application of new flavonoids Hyd. Background technique [0002] Seabuckthorn (Latin scientific name: Hippophae rhamnoides Linn.) is a deciduous shrub of the family Echinaceae and the genus Hippophae. It is characterized by drought resistance, wind and sand resistance, and can survive on salinized land, so it is widely used in soil and water conservation. . Seabuckthorn is grown in large quantities in northwest China for desert greening. [0003] Seabuckthorn is rich in nutrition, including active substances such as multivitamins, flavonoids, triterpenoids, oils and fatty acids, phenols, volatile oils, trace elements, phospholipids, 5-hydroxytryptamine, and various amino acids and proteins needed by the human body. [0004] Seabuckthorn seeds are often used to extract oil to make seabuckthorn oil. Seabuckthorn oil contains 206 kinds of active substan...

Claims

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Application Information

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IPC IPC(8): A61K31/7028A61K36/185A61P9/00A61P25/00A61P9/06A61P9/10A61P25/08A61P25/28A61P25/16A61P25/14A23L33/105
CPCA61K31/7028A61K36/185A61P9/00A61P25/00A61P9/06A61P9/10A61P25/08A61P25/28A61P25/16A61P25/14A23L33/105A23V2002/00A23V2200/322A23V2250/2116
Inventor 王振华丁金李刚
Owner YANTAI UNIV
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