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Chinese medicinal composition and related preparations thereof

A composition and drug technology, applied in the direction of drug combination, drug delivery, active ingredients of hydroxyl compounds, etc., can solve the problems of rare methods and related preparations, and achieve the effects of protecting brain tissue, improving energy metabolism, and inhibiting thrombus formation

Active Publication Date: 2007-08-08
BEIJING UNIV OF CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, there are few pure Chinese medicine preparations that have the effect of treating ischemic cerebral apoplexy in the acute stage and the early recovery stage, and the method of separating the effective parts from the pure Chinese medicine preparations and related preparations are also rare.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0025] Experimental example 1 Effect of effective parts of the present invention on neurological symptoms and cerebral infarction range in middle cerebral artery thrombosis model rats

[0026] 1. Experimental materials

[0027] 1.1 Drugs and reagents

[0028] Test drug: the effective part for the treatment of ischemic stroke in the acute phase and early recovery phase. The clinical dosage is 0.56 grams per person per day, about 10 mg / kg body weight, prepared with drinking water.

[0029] Positive control drug: Angong Niuhuang Pills, produced by Beijing Tongrentang Pharmaceutical Factory, orally, 1 time / day, 1 pill / day, each pill containing 3g of crude drug. Efficacy: clearing heat and detoxifying, calming convulsions and resuscitating. Batch number: 1010383.

[0030] Reagents and medicines: FeCl 3 ·6H 2 O(A.R.), a product of Beijing Chemical Plant, prepared with 1mol / L hydrochloric acid; red tetrazolium (TTC), a product of Beijing Chemical Plant, batch number: 960307.

...

experiment example 2

[0056] Experimental Example 2 Effects of effective parts of the present invention on the morphology of brain tissue in MCAT rats

[0057] See Experimental Example 1 for grouping, administration methods, and modeling methods. One hour after the last administration (i.e. 24 hours after surgery), the brain was decapitated, fixed with 20% formaldehyde and Carnoy’s solution, and brain slices were taken before and after the optic chiasm. , for HE and toluidine ryany body staining, observation of tissue morphology changes. Image analysis was performed on the results of Nissal staining (three fields of view were taken from the infarct for each sample, and three samples were taken in each group). The results are shown in Table 3.

[0058] Table 3 Effects of effective fractions on positive cells after Nissal staining in the cerebral cortex of MCAT rats

[0059] group

Dose (mg / kg)

N

Positive cell area density

mock surgical group

MCAT mod...

experiment example 3

[0062] Experimental Example 3 Effects of Effective Parts of the Present Invention on Rat Arteriovenous Bypass Thrombosis

[0063] The rats were randomly divided into five groups, namely the thrombosis model group, Qingnao Xuanqiao Dropping Pills 20mg / kg, 60mg / kg, 180mg / kg groups (respectively equivalent to 2 times, 6 times, 18 times the human dosage), Tianbaoning 24mg / kg group. Intragastric administration was administered once a day for a total of three administrations. Modeling was established one hour after the last administration, and the same amount of drinking water (1ml / 100g body weight) was given to the thrombosis model group, and surgery was performed one hour after the last administration.

[0064] Experimental rats were anesthetized by intraperitoneal injection of 0.35 g / kg 10% chloral hydrate, fixed in the supine position, operated on, and separated the right common carotid artery and left external jugular vein. Connect three sections of polyethylene tubing, one en...

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Abstract

The invention discloses a Chinese medicinal composition for treating cerebral apoplexy and related preparations thereof, wherein the medicinal composition comprises notoginseng, cape jasmine, boneol, and can be used for treating acute stage and early recovery stage of ischemic stroke with sure curative effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and related preparations, in particular to a traditional Chinese medicine composition for treating cerebral apoplexy and related preparations. Background technique [0002] Cerebral stroke is a group of diseases with cerebral ischemia and hemorrhagic injury symptoms as the main clinical manifestations, also known as stroke or cerebrovascular accident, with a very high mortality rate and disability rate, mainly divided into hemorrhagic stroke ( Cerebral hemorrhage or subarachnoid hemorrhage) and ischemic stroke (cerebral infarction, cerebral thrombosis), with cerebral infarction being the most common. Its essence is the lesion of the cerebral artery or the carotid artery innervating the brain, causing focal blood circulation disorder, and then leading to acute or subacute brain damage. The most common symptom is that patients have different degrees of language, motor, and sensory dysfu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/744A61K36/258A61K31/045A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P9/10A61P25/00A61P39/06
Inventor 石任兵王永炎顾海鸥孙建宁王玉蓉刘斌张允岭赵现红陈玉平张绍来
Owner BEIJING UNIV OF CHINESE MEDICINE
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