Chinese medicine effective part for treating cerebral apoplexy and its separation preparing process

A technology for effective parts and stroke, applied in medical preparations containing active ingredients, active ingredients of hydroxyl compounds, pharmaceutical formulas, etc., can solve the problem of rare methods and related preparations, and achieve the protection of brain tissue and reduce nerve damage. , the effect of improving energy metabolism

Active Publication Date: 2007-03-21
BEIJING UNIV OF CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, there are few pure Chinese medicine preparations that have the effect of treating ischemic cerebral apoplexy in the acute stage and the early recovery stage, and the method of separating the effective parts from the pure Chinese medicine preparations and related preparations are also rare.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0025] Experimental example 1 Effect of effective parts of the present invention on neurological symptoms and cerebral infarction range in middle cerebral artery thrombosis model rats

[0026] 1. Experimental materials

[0027] 1.1 Drugs and reagents

[0028] Test drug: the effective part for the treatment of ischemic stroke in the acute phase and early recovery phase. The clinical dosage is 0.56 grams per person per day, about 10 mg / kg body weight, prepared with drinking water.

[0029] Positive control drug: Angong Niuhuang Pills, produced by Beijing Tongrentang Pharmaceutical Factory, orally, 1 time / day, 1 pill / day, each pill containing 3g of crude drug. Efficacy: clearing heat and detoxifying, calming convulsions and resuscitating. Batch number: 1010383.

[0030] Reagents and medicines: FeCl 3 ·6H 2 O(A.R.), a product of Beijing Chemical Plant, prepared with 1mol / L hydrochloric acid; red tetrazolium (TTC), a product of Beijing Chemical Plant, batch number: 960307.

...

experiment example 2

[0054] Experimental Example 2 The effect of the effective parts of the present invention on the morphology of the brain tissue of MCAT rats. Grouping, administration methods, and modeling methods are shown in Experimental Example 1. One hour after the last administration (i.e. 24 hours after the operation), the brain was decapitated and taken, respectively. Fix them with 20% formaldehyde and Carnoy's solution, take brain slices before and after the optic chiasm, and stain with HE and toluidine-Rayney body to observe the changes in tissue morphology. Image analysis was performed on the results of Nissal staining (three fields of view were taken from the infarct for each sample, and three samples were taken in each group). The results are shown in Table 3.

[0055] group

Dose (mg / kg)

N

Positive cell area density

mock surgical group

MCAT model group

effective part group

Angong Niuhuang Pill Group

-

-

180 ...

experiment example 3

[0058] Experimental Example 3 Effects of Effective Parts of the Present Invention on Arteriovenous Bypass Thrombosis Formation in Rats

[0059] The rats were randomly divided into five groups, namely the thrombosis model group, Qingnao Xuanqiao Dropping Pills 20mg / kg, 60mg / kg, 180mg / kg groups (respectively equivalent to 2 times, 6 times, 18 times the human dosage), Tianbaoning 24mg / kg group. Intragastric administration was administered once a day for a total of three administrations. Modeling was established one hour after the last administration, and the same amount of drinking water (1ml / 100g body weight) was given to the thrombosis model group, and surgery was performed one hour after the last administration.

[0060] Experimental rats were anesthetized by intraperitoneal injection of 0.35 g / kg 10% chloral hydrate, fixed in the supine position, operated on, and separated the right common carotid artery and left external jugular vein. Connect three sections of polyethylene ...

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PUM

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Abstract

The invention discloses the Chinese medicinal composition effective position for treating cerebral apoplexy and related preparations thereof, wherein the effective position is prepared through mixing notoginseng and cape jasmine homogeneously, making clear grease by thin ethanol return flow extraction, dispersing with water, adsorbing with macroscopic adsorption resin, water washing and eluting the absorbed substance on the resin columns with thin ethanol, collecting the eluent, depression reclaiming the eluent, charging borneol and mixing homogeneously.

Description

technical field [0001] The invention relates to an effective part of a traditional Chinese medicine and a separation and preparation method thereof, in particular to an effective part of a traditional Chinese medicine for treating cerebral apoplexy and a separation and preparation method thereof. Background technique [0002] Cerebral stroke is a group of diseases with cerebral ischemia and hemorrhagic injury symptoms as the main clinical manifestations, also known as stroke or cerebrovascular accident, with a very high mortality rate and disability rate, mainly divided into hemorrhagic stroke ( Cerebral hemorrhage or subarachnoid hemorrhage) and ischemic stroke (cerebral infarction, cerebral thrombosis), with cerebral infarction being the most common. Its essence is the lesion of the cerebral artery or the carotid artery innervating the brain, causing focal blood circulation disorder, and then leading to acute or subacute brain damage. The most common symptom is that patie...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/744A61K36/258A61K31/704A61K31/7048A61K31/045A61P9/10
Inventor 石任兵王永炎顾海鸥孙建宁王玉蓉刘斌张允岭赵现红陈玉平张绍来
Owner BEIJING UNIV OF CHINESE MEDICINE
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