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Method for extracting borneol from turpentine isomerization reaction liquid

A technology of isomerization reaction and turpentine, applied in the field of medicine and chemical industry, can solve the problems of orthoborneol waste and medical resource waste

Active Publication Date: 2020-10-30
福建南平青松化工有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the existing turpentine isomerization process, by-products such as orthoborneol, isoborneol, and longifolene are treated as low-value distillation still residues, which greatly causes the waste of orthoborneol, thereby resulting in a waste of medical resources

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] (1) Add metatitanic acid to the turpentine, the metatitanic acid is 1wt% of the weight of the turpentine, react at 110°C for 16 hours to obtain a reaction solution, the main products in the reaction solution are camphene and dipentene and contain Brain, isoborneol, longifolene and other heavy parts.

[0092] (2) enter rectifying tower A with the reaction solution that step (1) obtains with pump and carry out continuous rectification (the temperature of the tower still of rectifying tower A is 110 ℃, the vacuum degree of tower top 92Kpa, the vacuum degree of tower top, tower still The absolute value difference is 12Kpa, the output is 1000Kg / h, and the reflux ratio is 3:1), camphene is extracted from the tower top of tower A, and the tower still material of tower A is transferred to the rectifying tower that cooperates with rectifying tower A B carries out continuous rectification (the temperature of the tower still of rectifying tower B is 130 ℃, and the vacuum degree of...

Embodiment 2

[0095] The present embodiment is the same as Example 1, and the difference is that in the step (2), when the borneol oil is extracted in the rectifying tower C, the reflux ratio is controlled at 2:1, and the purity of the orthoborneol crystals obtained is was 85.7%.

Embodiment 3

[0097] This example is the same as Example 1, except that in the step (3), the precipitated crude borneol is dissolved in ethanol at 60° C., and the purity of the orthoborneol crystals obtained is 81.7%.

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PUM

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Abstract

The invention relates to a method for extracting borneol from turpentine isomerization reaction liquid. Specifically, the invention provides a method for extracting the borneol from the turpentine isomerization reaction liquid, and the method comprises the following steps: (1) providing the turpentine isomerization reaction liquid; (2) feeding the turpentine isomerization reaction liquid into a first rectifying tower for rectifying, extracting camphene from the tower top of the first rectifying tower, transferring a tower kettle material of the first rectifying tower into a second rectifying tower for rectifying, extracting dipentene from the tower top of the second rectifying tower, transferring a tower kettle material of the second rectifying tower into a third rectifying tower for rectifying, and extracting borneol oil from the tower top of the third rectifying tower; and (3) crystallizing the borneol oil at 5-12 DEG C, carrying out centrifugal separation to obtain crude borneol, dissolving the crude borneol in an organic solvent, crystallizing at room temperature, and separating to obtain the borneol. The method provided by the invention can effectively extract the by-product borneol of the turpentine isomerization reaction liquid, and the extracted borneol has excellent purity.

Description

technical field [0001] The invention relates to the field of medicine and chemical industry, in particular to a method for extracting orthoborneol from turpentine isomerization reaction liquid. Background technique [0002] Borneol (Borneol) has great medical value. Borneol has significant effects in many aspects such as antibacterial, anti-inflammatory, pain relief, and anti-fertility. Many Chinese patent medicines use it as one of the main components of drugs, such as Bingboran Powder , Niuhuangjiedu pills, Angong Niuhuang pills, Niuhuang Shangqing pills, Suhexiang pills, etc. [0003] There are two epimers of orthoborneol and isoborneol in borneol. However, the side effects of isoborneol are much greater than that of orthoborneol, and the resources of orthoborneol are very limited. Therefore, the price of orthoborneol is lower than that of isoborneol. It is much more expensive, and the high price of orthoborneol greatly limits the increasing demand of human beings. There...

Claims

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Application Information

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IPC IPC(8): C07C35/30C07C29/74C07C29/80C07C29/78C07C13/40C07C13/21C07C7/04
CPCC07C29/74C07C29/80C07C29/78C07C7/04C07C2602/42C07C2601/16C07C35/30C07C13/40C07C13/21
Inventor 苏江波邓新贵吴德斌胡正财杨斌
Owner 福建南平青松化工有限公司