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Application of miR-122-5p as renal fibrosis non-invasive diagnostic marker and detection kit

A kidney fibrosis and kit technology, applied in the field of biomedicine, can solve the problems of limited clinical application and high cost, and achieve the effect of important clinical application value

Inactive Publication Date: 2020-10-30
武汉市皮诺飞生物科技有限公司
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Problems solved by technology

The most reliable direct diagnosis method for renal fibrosis is renal biopsy, but renal biopsy is an invasive examination, expensive and limited in clinical application

Method used

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  • Application of miR-122-5p as renal fibrosis non-invasive diagnostic marker and detection kit
  • Application of miR-122-5p as renal fibrosis non-invasive diagnostic marker and detection kit
  • Application of miR-122-5p as renal fibrosis non-invasive diagnostic marker and detection kit

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Embodiment Construction

[0017] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention. In addition, the technical features involved in the various embodiments of the present invention described below can be combined with each other as long as they do not constitute a conflict with each other.

[0018] In order to effectively prevent and control renal fibrosis damage caused by renovascular hypertension, and to conduct non-invasive and accurate dynamic monitoring of the pathogenesis of fibrosis, the present invention provides a non-invasive diagnostic biomarker miR-122-5p molecule, the sequence of which is SEQ ID No. The nucleic acid sequence shown in 1.

[0019] 1. Establishment of ren...

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Abstract

The invention relates to an application of miR-122-5p as a renal fibrosis diagnosis marker, and an application of the miR-122-5p as renal vascular hypertension. The invention also relates to a kit fordiagnosing renal fibrosis. The kit comprises a detection agent for detecting the expression quantity of miR-122-5p. By using the miR-122-5p expression quantity in the peripheral blood as a molecularmarker, noninvasive detection can be performed on renal vascular hypertension and renal fibrosis injury caused by the renal vascular hypertension, noninvasive dynamic monitoring is performed on the lesion process of the renal vascular hypertension, and important clinical application value is achieved.

Description

technical field [0001] The invention belongs to the field of biomedicine, and more specifically relates to the application of miR-122-5p as a diagnostic marker of renal fibrosis and a detection kit based on the diagnostic marker. Background technique [0002] Fibrosis is a progressive pathological process that can lead to organ damage and even functional failure. Renal fibrosis is primarily characterized by the deposition of pathological fibrous matrix in the areas between the renal tubules and peritubular capillaries. Under pathological conditions, renal tubular epithelial cells can differentiate into mesenchymal cells and activated fibroblasts, and finally myofibroblasts. This process is called epithelial-mesenchymal transition (Epithelial–Mesenchymal Transition, EMT). [0003] Renovascular hypertension can lead to renal fibrosis and even renal failure, and fibrosis is a gradual process. Therefore, the diagnosis of renovascular hypertension is conducive to the control of ...

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Application Information

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IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/158C12Q2600/178
Inventor 李勇姚雨峰许少刚
Owner 武汉市皮诺飞生物科技有限公司
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