Three-dimensional connective porous artificial bone scaffold as well as preparation method and application thereof

An artificial bone, three-dimensional technology, applied in medical science, prosthesis, etc., can solve the problems of poor mechanical strength, fragility, and poor connectivity of micropores, and achieve the effects of improving mechanical strength, promoting new bone growth, and simplifying the process

Active Publication Date: 2014-11-19
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
View PDF6 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing porous β-TCP artificial bone products are made by high-temperature sintering of chemically synthesized β-TCP powder. These materials are brittle, have poor mechanical strength, an

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Three-dimensional connective porous artificial bone scaffold as well as preparation method and application thereof
  • Three-dimensional connective porous artificial bone scaffold as well as preparation method and application thereof
  • Three-dimensional connective porous artificial bone scaffold as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0030] Example 1

[0031] Raw materials and requirements: stone pen sea urchin spines and diammonium hydrogen phosphate (analytical pure).

[0032] Mechanical processing: Cut sea urchin spines into granular samples ~ 2mm x 2mm x 2mm.

[0033] Removal of organic matter and impurities: the sea urchin thorn sample is immersed in deionized water and boiled for 30 minutes, and ultrasonically vibrated for 40 minutes in a 10 wt.% NaClO solution to remove organic matter and impurities in the sea urchin thorn. After taking it out, rinse it with deionized water three times and then dry it in a vacuum drying oven at 100°C.

[0034] Hydrothermal reaction: the granular sea urchin spines with (NH 4 ) 2 HPO 4 Mix according to the weight ratio of 1:2 and place it in the hydrothermal reactor, (NH 4 ) 2 HPO 4 The solution concentration is 10wt.%, and the hydrothermal reaction is carried out at 180℃ for 48 hours. The hydrothermal reaction product is washed and dried to prepare a granular porous β-TCP ar...

Example Embodiment

[0035] Example 2

[0036] Raw materials and requirements: stone pen sea urchin spines and diammonium hydrogen phosphate (analytical pure).

[0037] Mechanical processing: Cut sea urchin spines into granular samples ~ 2mm x 2mm x 2mm.

[0038] Removal of organic matter and impurities: the sea urchin thorn sample is immersed in deionized water and boiled for 30 minutes, and ultrasonically vibrated for 40 minutes in a 10 wt.% NaClO solution to remove organic matter and impurities in the sea urchin thorn. After taking it out, rinse it with deionized water three times and then dry it in a vacuum drying oven at 100°C.

[0039] Hydrothermal reaction: the granular sea urchin spines with (NH 4 ) 2 HPO 4 Mix according to the weight ratio of 1:2 and place it in the hydrothermal reactor, (NH 4 ) 2 HPO 4 The solution concentration is 10wt.%, the hydrothermal reaction is carried out at 160°C for 96 hours, and the hydrothermal reaction product is washed and dried to prepare a granular porous Mg-cont...

Example Embodiment

[0040] Example 3

[0041] Raw materials and requirements: stone pen sea urchin spines and diammonium hydrogen phosphate (analytical pure).

[0042] Mechanical processing: Cut sea urchin spines into granular samples ~ 2mm x 2mm x 2mm.

[0043] Removal of organic matter and impurities: the sea urchin thorn sample is immersed in deionized water and boiled for 30 minutes, and ultrasonically vibrated for 40 minutes in a 10 wt.% NaClO solution to remove organic matter and impurities in the sea urchin thorn. After taking it out, rinse it with deionized water three times and then dry it in a vacuum drying oven at 100°C.

[0044] Hydrothermal reaction: the granular sea urchin spines with (NH 4 ) 2 HPO 4 Mix according to the weight ratio of 1:2 and place it in the hydrothermal reactor, (NH 4 ) 2 HPO 4 The solution concentration is 10wt.%, the hydrothermal reaction is carried out at 220°C for 24 hours, the hydrothermal reaction product is washed and dried to prepare a granular porous Mg-containi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a three-dimensional connective porous artificial bone scaffold as well as a preparation method and application thereof and belongs to the technical field of biological materials. The magnesium-containing beta-TCP (beta-tertiary calcium phosphate) artificial bone scaffold is prepared by utilizing the unique microscopic structure of natural sea urchin and the hydro-thermal synthesis, and is of a three-dimensional connective porous structure, wherein the porosity is 50-70 percent, and the structure is beneficial to new bone regeneration in bone defect repairing. The three-dimensional connective porous artificial bone scaffold comprises granular and cylindrical artificial bone materials, a porous artificial bone scaffold for filling an interbody fusion cage and the like, and is applicable to bone defect filling, small-cake bone replacing and spinal fusing. Compared with an existing pottery firing method, the preparation method has the advantages that the experimental process is remarkably simplified, and artificial bone materials with different shapes and sizes for meeting requirements of bone injured patients can be produced by means of mechanical processing, and has important clinical application value.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a three-dimensional interconnected porous artificial bone scaffold and its preparation method and application. Background technique [0002] Calcium phosphate bioceramic materials (including hydroxyapatite and tricalcium phosphate) are mainly used in orthopedic surgery for bone fracture repair, artificial joint repair, and injectable bone graft materials for the treatment of osteoporosis. It is used for various spinal defect indications such as posterior spinal fusion, and is mainly used for tooth extraction trauma and maxillofacial surgery in dentistry. Calcium phosphate bioceramic materials have good biocompatibility because they are similar to the inorganic salts of human bones, and have good osseointegration ability after implantation in vivo. Among them, β-phase tricalcium phosphate (β-TCP) artificial bone ceramics can also be absorbed by the human body. degradation. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L27/12A61L27/36A61L27/56
Inventor 张兴杨丽娜杨锐
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap