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Three-dimensional connective porous artificial bone scaffold as well as preparation method and application thereof

An artificial bone, three-dimensional technology, applied in medical science, prosthesis, etc., can solve the problems of poor mechanical strength, fragility, and poor connectivity of micropores, and achieve the effects of improving mechanical strength, promoting new bone growth, and simplifying the process

Active Publication Date: 2014-11-19
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing porous β-TCP artificial bone products are made by high-temperature sintering of chemically synthesized β-TCP powder. These materials are brittle, have poor mechanical strength, and are easily broken during implantation operations; other porous β-TCP artificial bone products Poor connectivity of micropores is not conducive to new bone ingrowth in bone defect repair

Method used

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  • Three-dimensional connective porous artificial bone scaffold as well as preparation method and application thereof
  • Three-dimensional connective porous artificial bone scaffold as well as preparation method and application thereof
  • Three-dimensional connective porous artificial bone scaffold as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Raw materials and requirements: slate sea urchin spines and diammonium hydrogen phosphate (analytical grade).

[0032] Mechanical processing: cut sea urchin spines into granular samples ~2mm x2mm x2mm.

[0033] Removal of organic matter and impurities: the sea urchin spine sample was immersed in deionized water and boiled for 30 minutes, and ultrasonically oscillated in 10wt.% NaClO solution for 40 minutes to remove the organic matter and impurities in the sea urchin spine. After taking it out, wash it three times with deionized water and dry it in a vacuum oven at 100°C.

[0034] Hydrothermal reaction: the granular sea urchin spines and (NH 4 ) 2 HPO 4According to the weight ratio of 1:2, it is mixed and placed in a hydrothermal reaction kettle, (NH 4 ) 2 HPO 4 The concentration of the solution is 10wt.%, and the hydrothermal reaction is carried out at 180° C. for 48 hours, and the hydrothermal reaction product is washed and dried to prepare a granular porous Mg-...

Embodiment 2

[0036] Raw materials and requirements: slate sea urchin spines and diammonium hydrogen phosphate (analytical grade).

[0037] Mechanical processing: cut sea urchin spines into granular samples ~2mm x2mm x2mm.

[0038] Removal of organic matter and impurities: the sea urchin spine sample was immersed in deionized water and boiled for 30 minutes, and ultrasonically oscillated in 10wt.% NaClO solution for 40 minutes to remove the organic matter and impurities in the sea urchin spine. After taking it out, wash it three times with deionized water and dry it in a vacuum oven at 100°C.

[0039] Hydrothermal reaction: the granular sea urchin spines and (NH 4 ) 2 HPO 4 According to the weight ratio of 1:2, it is mixed and placed in a hydrothermal reaction kettle, (NH 4 ) 2 HPO 4 The concentration of the solution is 10wt.%, and the hydrothermal reaction is carried out at 160°C for 96 hours. The hydrothermal reaction product is washed and dried to prepare a granular porous Mg-conta...

Embodiment 3

[0041] Raw materials and requirements: slate sea urchin spines and diammonium hydrogen phosphate (analytical grade).

[0042] Mechanical processing: cut sea urchin spines into granular samples ~2mm x2mm x2mm.

[0043] Removal of organic matter and impurities: the sea urchin spine sample was immersed in deionized water and boiled for 30 minutes, and ultrasonically oscillated in 10wt.% NaClO solution for 40 minutes to remove the organic matter and impurities in the sea urchin spine. After taking it out, wash it three times with deionized water and dry it in a vacuum oven at 100°C.

[0044] Hydrothermal reaction: the granular sea urchin spines and (NH 4 ) 2 HPO 4 According to the weight ratio of 1:2, it is mixed and placed in a hydrothermal reaction kettle, (NH 4 ) 2 HPO 4 The concentration of the solution is 10wt.%, and the hydrothermal reaction is carried out at 220°C for 24 hours. The hydrothermal reaction product is washed and dried to prepare a granular porous Mg-conta...

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Abstract

The invention discloses a three-dimensional connective porous artificial bone scaffold as well as a preparation method and application thereof and belongs to the technical field of biological materials. The magnesium-containing beta-TCP (beta-tertiary calcium phosphate) artificial bone scaffold is prepared by utilizing the unique microscopic structure of natural sea urchin and the hydro-thermal synthesis, and is of a three-dimensional connective porous structure, wherein the porosity is 50-70 percent, and the structure is beneficial to new bone regeneration in bone defect repairing. The three-dimensional connective porous artificial bone scaffold comprises granular and cylindrical artificial bone materials, a porous artificial bone scaffold for filling an interbody fusion cage and the like, and is applicable to bone defect filling, small-cake bone replacing and spinal fusing. Compared with an existing pottery firing method, the preparation method has the advantages that the experimental process is remarkably simplified, and artificial bone materials with different shapes and sizes for meeting requirements of bone injured patients can be produced by means of mechanical processing, and has important clinical application value.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a three-dimensional interconnected porous artificial bone scaffold and its preparation method and application. Background technique [0002] Calcium phosphate bioceramic materials (including hydroxyapatite and tricalcium phosphate) are mainly used in orthopedic surgery for bone fracture repair, artificial joint repair, and injectable bone graft materials for the treatment of osteoporosis. It is used for various spinal defect indications such as posterior spinal fusion, and is mainly used for tooth extraction trauma and maxillofacial surgery in dentistry. Calcium phosphate bioceramic materials have good biocompatibility because they are similar to the inorganic salts of human bones, and have good osseointegration ability after implantation in vivo. Among them, β-phase tricalcium phosphate (β-TCP) artificial bone ceramics can also be absorbed by the human body. degradation. ...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/36A61L27/56
Inventor 张兴杨丽娜杨锐
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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