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Axial high-resolution photoacoustic imaging method and system using high-frequency probe and low-frequency probe in cooperation

A photoacoustic imaging, high-resolution technology, applied in application, medical science, diagnostic signal processing, etc., can solve the problem of low axial resolution, achieve the effect of expanding the application range and improving axial resolution

Inactive Publication Date: 2020-11-17
NANCHANG UNIV
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Problems solved by technology

[0003] The technical problem to be solved by the present invention is to overcome the problem of low axial resolution in the photoacoustic microscopy imaging system in the prior art, and to provide a photoacoustic microscopy that can obtain high axial resolution using high and low frequency probes. Imaging method and system

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  • Axial high-resolution photoacoustic imaging method and system using high-frequency probe and low-frequency probe in cooperation

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Embodiment 1

[0027] figure 1 It is a schematic diagram of the principle structure of the whole imaging system of the present invention. The main components of the system include a pump laser 1, a first objective lens 2, an optical fiber 3, a first condenser lens 4, a first and a second objective lens 5, a first focused ultrasonic probe 6, a second focused ultrasonic probe 7, and a three-dimensional scanner 10. It consists of a signal amplifier 11, a signal acquisition card 12, and a workstation 13. The pump laser 1 is used to emit a laser beam. After the laser is emitted, it is coupled into the optical fiber 3 through the first objective lens 2, collimated by the first condenser lens 4, and then focused on the sample 9 by the second objective lens 5 to generate photoacoustic signals. The first focused ultrasound probe 6 and the second focused ultrasound probe 7 with center frequencies of 25MHz and 50MHz (both bandwidths are 80%) are symmetrically placed on both sides of the second objecti...

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Abstract

The invention relates to an axial high-resolution photoacoustic imaging method and device system using a high-frequency probe and a low-frequency probe in cooperation. The system comprises a laser generator, objective lenses, two focusing type ultrasonic probes with different center frequencies, a three-dimensional scanner, a signal acquisition card and a workstation. The axial high-resolution imaging requirement of a photoacoustic microscopic imaging system is met. According to the axial high-resolution photoacoustic imaging method using the high-frequency probe and the low-frequency probe incooperation, the two focusing type ultrasonic probes with different center frequencies are mainly used, the ultrasonic probes with different center frequencies can detect different spectrum scopes, and photoacoustic signal frequency spectrums obtained by the two probes with different center frequencies are fused to obtain an expanded photoacoustic signal frequency spectrum, so that the axial resolution of the system is improved. Through the adoption of the method, the system can reflect the three-dimensional structure information of samples more truly, and the application range of photoacoustic microscopic imaging is expanded.

Description

technical field [0001] The invention relates to the field of photoacoustic microscopic imaging, in particular to an axial high-resolution photoacoustic imaging method and system using high and low frequency probes. Background technique [0002] After more than 20 years of development, photoacoustic imaging has become one of the fastest growing biological imaging technologies. According to the form of light excitation and acoustic detection, there are two main types of photoacoustic imaging: photoacoustic tomography (PAT) and photoacoustic microscopy (PAM). PAT uses wide-field illumination and ultrasound detection at multiple locations, which can provide relatively low spatial resolution (on the order of hundreds of microns) and deep imaging depth (several centimeters); PAM uses strongly or weakly focused illumination and Focused ultrasound detection can provide high spatial resolution (from several microns to tens of microns) and relatively shallow imaging depth (one to sev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
CPCA61B5/0095A61B5/72
Inventor 宋贤林王玉皞周辉林魏剑霜宋玲芳骆清铭
Owner NANCHANG UNIV
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