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Preparation method of liquid dressing with analgesic and antibacterial effects

A liquid dressing and functional technology, applied in the field of medical supplies, can solve the problems of wound maceration bacteria, low mechanical strength, difficult to handle, etc., and achieve the effects of simple composition, short film-forming time, and prevention of epidermal adhesion

Pending Publication Date: 2020-11-27
SHANDONG BRANDEN MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

One of the major disadvantages of hydrogel dressings as wound dressings is that the accumulation of exudate can lead to wound maceration and bacterial proliferation; moreover, the low mechanical strength of hydrogels makes them difficult to handle

Method used

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  • Preparation method of liquid dressing with analgesic and antibacterial effects
  • Preparation method of liquid dressing with analgesic and antibacterial effects
  • Preparation method of liquid dressing with analgesic and antibacterial effects

Examples

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preparation example Construction

[0022] The invention discloses a preparation method of a liquid dressing with analgesic and antibacterial functions, the operation steps of which are as follows:

[0023] (1) Accurately weigh the required chitosan quaternary ammonium salt, analgesic, preservative, vitamin C, xanthan gum and humectant by analytical balance in the weighing laboratory, accurate to two decimal places;

[0024] (2) Accurately measure the ultrapure water required for preparation by graduated cylinder and pipette;

[0025] (3) Add 1⁄2 of the total amount of ultrapure water to the concentrated tank, then add the weighed chitosan quaternary ammonium salt, and stir at a speed of 100~150r / min at room temperature until the chitosan The sugar quaternary ammonium salt is completely dissolved to obtain solution A;

[0026] (4) Add an analgesic, preservative, and vitamin C to solution A in turn, and stir at a speed of 30 to 100 r / min for 30 to 60 minutes at room temperature to make it evenly mixed to obtain ...

Embodiment 1

[0033] The liquid dressing with analgesic and antibacterial functions described in this implementation, in terms of mass percentage, it consists of chitosan quaternary ammonium salt 15%, analgesic 1%, preservative 0.3%, vitamin C 1%, xanthan gum 1% , moisturizing agent 1% and ultrapure water 80.7% composition:

[0034] (1) Accurately weigh 15.01g chitosan quaternary ammonium salt, 1.02g lidocaine, 0.30g sodium benzoate, 1.01g vitamin C, 1.00g xanthan gum and 1.00g Glycerin, accurate to two decimal places;

[0035] (2) Accurately measure 80.7ml of ultrapure water required for preparation by graduated cylinder and pipette;

[0036] (3) add the ultrapure water of 40ml in the concentrated irrigation, then add the chitosan quaternary ammonium salt weighed, at normal temperature, stir with the speed of 120r / min, stir until the chitosan quaternary ammonium salt dissolves completely, Obtain solution A;

[0037] (4) Add lidocaine, sodium benzoate, vitamin C successively in solution A,...

Embodiment 2

[0044] The liquid dressing with analgesic and antibacterial functions described in this implementation, in terms of mass percentage, it consists of chitosan quaternary ammonium salt 12%, analgesic 1%, preservative 0.2%, vitamin C 1%, xanthan gum 1% , moisturizing agent 1% and ultrapure water 83.8% composition:

[0045] (1) Accurately weigh 12.00g chitosan quaternary ammonium salt, 1.00g lidocaine, 0.20g sodium benzoate, 1.00g vitamin C, 1.00g xanthan gum and 1.00g Glycerin, accurate to two decimal places;

[0046] (2) Accurately measure 83.8ml of ultrapure water required for preparation by graduated cylinder and pipette;

[0047] (3) add the ultrapure water of 40ml in the concentrated irrigation, then add the chitosan quaternary ammonium salt weighed, at normal temperature, stir with the speed of 140r / min, stir until the chitosan quaternary ammonium salt dissolves completely, Obtain solution A;

[0048] (4) Add lidocaine, sodium benzoate, vitamin C successively in solution ...

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Abstract

The invention discloses a liquid dressing with analgesic and antibacterial effects and a preparation method of the liquid dressing, and belongs to the technical field of medical supplies. The main components of the method are chitosan quaternary ammonium salt, an analgesic, a preservative, ultrapure water, vitamin C, xanthan gum and a humectant. The liquid dressing is designed in a liquid state, is convenient, simple and rapid to use and is suitable for groups of different ages. When the liquid dressing is used, a small amount of dressing can be taken out and smeared on a wound surface, and the liquid dressing can also be smeared on the wound surface in a spray administration mode. After administration, the dressing can form a layer of thin film on a wound surface to cover the wound and isolate the wound from air, so that wound infection is avoided; and meanwhile, a moist environment required by wound healing is provided, and rapid healing of the wound is facilitated. The liquid dressing provided by the invention has the advantages of simple preparation method, low production cost, safe components, no irritation to skin and the like, and can be used for nursing common wounds such as incisions, scratches and the like.

Description

technical field [0001] The invention belongs to the technical field of medical supplies, and in particular relates to a liquid dressing with analgesic and antibacterial functions and a preparation method thereof. Background technique [0002] When the shape and function of the skin are disrupted by internal or external factors, the damaged place is a wound. Wound healing is an extremely complex process that requires the replacement of inactive or missing cellular structures and tissue layers. Wound healing is highly dynamic, and is generally divided into four stages according to the degree of healing: inflammation, proliferation, granulation, and tissue remodeling. Before the 18th century, wound care mainly relied on the experience handed down from the predecessors. The wound healing was mainly natural healing and natural materials were used to assist the wound. This process was relatively slow and prone to infection; in the 19th century, microbiologist Pasteur discovered t...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0066A61L26/0061A61L2300/232A61L2300/404A61L2300/402
Inventor 张海军鞠豪尹玉霞侯文博刘爱华张明广卢天恒曹明昆
Owner SHANDONG BRANDEN MEDICAL DEVICE
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