Antifungal pharmaceutical composition, preparation method thereof and film-forming gel

A technology of antifungal drugs and compositions, applied in the field of pharmaceutical preparations, to achieve the effects of improving compliance, reducing inconvenience, and good film-forming effect

Active Publication Date: 2020-12-04
BRIGHT FUTURE PHARMA LAB LTD (CN)
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of this application is to provide an antifungal pharmaceutical composition and its preparation metho

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antifungal pharmaceutical composition, preparation method thereof and film-forming gel
  • Antifungal pharmaceutical composition, preparation method thereof and film-forming gel
  • Antifungal pharmaceutical composition, preparation method thereof and film-forming gel

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0039] A second aspect of the embodiments of the present application provides a method for preparing an antifungal pharmaceutical composition, comprising the following steps:

[0040] S01: provide each component of the above-mentioned antifungal pharmaceutical composition;

[0041] S02: adding the hydrophilic film-forming material and the auxiliary film-forming material to a plasticizer, dispersing and dissolving in a first solvent to obtain a first mixed solution;

[0042] S03: dissolving the hydrophobic film-forming material and the antifungal drug in a second solvent to obtain a second mixed solution;

[0043] S04: mixing the first mixed solution and the second mixed solution, avoiding light and swelling to obtain the antifungal pharmaceutical composition;

[0044] The first part of the solvent and the second part of the solvent make up the organic solvent.

[0045] The preparation method of the antifungal pharmaceutical composition provided by the present application is ...

Example Embodiment

[0051] Examples 1-8

[0052] The film-forming gel was prepared with the formula shown in Table 1 to investigate the film-forming system of different hydrophilic film-forming materials.

[0053] The preparation method is as follows: the first step: respectively taking different hydrophilic film-forming materials (hydroxypropyl cellulose, hydroxypropyl methylcellulose, xanthan gum or hydroxyethyl cellulose) and poloxamer 124, adding citric acid Stir the tributyl ester to make it evenly dispersed and set aside. The second step: take an appropriate amount of solvent (ethanol) and slowly add the dispersion prepared in the first step under stirring state, stir evenly and place it to fully swell for use; the third step: take an appropriate amount of solvent and add the hydrophobic film-forming material acrylic acid The ester / octyl acrylic acid copolymer and the antifungal drug terbinafine hydrochloride are stirred to be completely dissolved, for subsequent use; the fourth step: the ...

Example

[0057] Examples 9 to 12

[0058] The film-forming gel was prepared with the formula shown in Table 2 to investigate the film-forming systems of different hydrophobic film-forming materials.

[0059] The preparation method is as follows: the first step: taking hydroxypropyl cellulose and poloxamer 124, adding triethyl citrate and stirring to make it evenly dispersed, and then for use. The second step: take an appropriate amount of solvent (ethanol) and slowly add the dispersion obtained in the first step under stirring state, stir evenly and place it to fully swell for use; the third step: take an appropriate amount of solvent and add different hydrophobic film-forming materials (polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl butyral or acrylate / octyl acrylic acid copolymer) and antifungal drug clotrimazole, stir to make it completely dissolved, for use; fourth step: put in the third step The obtained solution was slowly added to the solution in the second step under stir...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to an antifungal pharmaceutical composition, a preparation method thereof and film-forming gel. The antifungal pharmaceutical composition comprises the following components in percentage by weight: 0.1-20% of hydrophilic film-forming material, 0.1-20% of hydrophobic film-forming material, 0.1-20%of auxiliary film-forming material, 0.1-15% of antifungal drug, 0.1-25% of plasticizer and 60-98% of organic solvent. The antifungal pharmaceutical composition provided by the invention has a good film-forming effect, can achieve a treatment effect on the premise of single use, and reduces the inconvenience of repeated use of the traditional external preparation.

Description

technical field [0001] The application belongs to the technical field of pharmaceutical preparations, and in particular relates to an antifungal pharmaceutical composition, a preparation method thereof and a film-forming gel. Background technique [0002] Skin fungal infection is usually an infection of the skin and hair caused by Candida, Trichophyton, Epidermophyton flocculus, etc., which requires the preparation to have certain release and penetration capabilities, and be able to enter the stratum corneum to exert curative effect. Chronic diseases require repeated use of drugs to ensure the therapeutic effect. If the fungal infection is not treated thoroughly, the symptoms will recur. Therefore, if the residence time of topical formulations on the skin can be extended while maintaining effective drug concentrations, the treatment of chronic skin diseases will be improved, and patient compliance will be improved at the same time. [0003] Traditional external preparations...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/70A61K9/06A61K47/38A61K47/32A61K47/10A61K45/06A61K31/137A61K31/4174A61K31/496A61P17/00A61P31/10
CPCA61K9/7015A61K9/06A61K47/38A61K47/32A61K47/10A61K45/06A61K31/137A61K31/4174A61K31/496A61P17/00A61P31/10
Inventor 张静林华庆奥姆·桑巴吉·谢尔克吴涛
Owner BRIGHT FUTURE PHARMA LAB LTD (CN)
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap