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Antifungal pharmaceutical composition, preparation method thereof and film-forming gel

A technology of antifungal drugs and compositions, applied in the field of pharmaceutical preparations, to achieve the effects of improving compliance, reducing inconvenience, and good film-forming effect

Active Publication Date: 2020-12-04
BRIGHT FUTURE PHARMA LAB LTD (CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of this application is to provide an antifungal pharmaceutical composition and its preparation method and film-forming gel, aiming to solve the technical problem of how to provide more antifungal coating gel preparations

Method used

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  • Antifungal pharmaceutical composition, preparation method thereof and film-forming gel
  • Antifungal pharmaceutical composition, preparation method thereof and film-forming gel
  • Antifungal pharmaceutical composition, preparation method thereof and film-forming gel

Examples

Experimental program
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Effect test

preparation example Construction

[0039] The second aspect of the embodiment of the present application provides a preparation method of an antifungal pharmaceutical composition, comprising the following steps:

[0040] S01: providing each component of the above-mentioned antifungal pharmaceutical composition;

[0041] S02: adding the hydrophilic film-forming material and the auxiliary film-forming material into a plasticizer, dispersing, and then dissolving in the first solvent to obtain a first mixed solution;

[0042] S03: dissolving the hydrophobic film-forming material and the antifungal drug in a second solvent to obtain a second mixed solution;

[0043] S04: Mix the first mixed solution with the second mixed solution, avoid light swelling, and obtain the antifungal pharmaceutical composition;

[0044] The first solvent and the second solvent constitute the organic solvent.

[0045] The preparation method of the antifungal pharmaceutical composition provided by the application is obtained by mixing and...

Embodiment 1-8

[0052] The film-forming gel was prepared with the formula shown in Table 1 to investigate the film-forming system of different hydrophilic film-forming materials.

[0053] The preparation method is as follows: the first step: take different hydrophilic film-forming materials (hydroxypropyl cellulose, hydroxypropyl methyl cellulose, xanthan gum or hydroxyethyl cellulose) and poloxamer 124 respectively, add citric acid Stir the tributyl ester to make it disperse evenly, set aside. Step 2: Take an appropriate amount of solvent (ethanol) and slowly add it to the dispersion prepared in the first step under stirring. After stirring evenly, let it swell fully and set aside; Step 3: Take an appropriate amount of solvent and add acrylic acid, a hydrophobic film-forming material Ester / octyl acrylic acid copolymer and antifungal drug terbinafine hydrochloride, stir to make it dissolve completely, and set aside; the fourth step: slowly add the solution obtained in the third step to the so...

Embodiment 9～12

[0058] The film-forming gel was prepared with the formula shown in Table 2 to investigate the film-forming system of different hydrophobic film-forming materials.

[0059] The preparation method is as follows: Step 1: Take hydroxypropyl cellulose and poloxamer 124, add triethyl citrate and stir to disperse evenly, set aside. Step 2: Take an appropriate amount of solvent (ethanol) and slowly add it to the dispersion prepared in the first step under stirring. After stirring evenly, let it swell fully and set aside; Step 3: Take an appropriate amount of solvent and add different hydrophobic film-forming materials (polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl butyral or acrylate / octyl acrylic acid copolymer) and the antifungal drug clotrimazole, stir to make it dissolve completely, and set aside; the fourth step: put the The obtained solution was slowly added to the solution in the second step under stirring, and ethanol was added quantitatively to 100%, and stirred evenly; ...

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PUM

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to an antifungal pharmaceutical composition, a preparation method thereof and film-forming gel. The antifungal pharmaceutical composition comprises the following components in percentage by weight: 0.1-20% of hydrophilic film-forming material, 0.1-20% of hydrophobic film-forming material, 0.1-20%of auxiliary film-forming material, 0.1-15% of antifungal drug, 0.1-25% of plasticizer and 60-98% of organic solvent. The antifungal pharmaceutical composition provided by the invention has a good film-forming effect, can achieve a treatment effect on the premise of single use, and reduces the inconvenience of repeated use of the traditional external preparation.

Description

technical field [0001] The application belongs to the technical field of pharmaceutical preparations, and in particular relates to an antifungal pharmaceutical composition, a preparation method thereof and a film-forming gel. Background technique [0002] Skin fungal infection is usually an infection of the skin and hair caused by Candida, Trichophyton, Epidermophyton flocculus, etc., which requires the preparation to have certain release and penetration capabilities, and be able to enter the stratum corneum to exert curative effect. Chronic diseases require repeated use of drugs to ensure the therapeutic effect. If the fungal infection is not treated thoroughly, the symptoms will recur. Therefore, if the residence time of topical formulations on the skin can be extended while maintaining effective drug concentrations, the treatment of chronic skin diseases will be improved, and patient compliance will be improved at the same time. [0003] Traditional external preparations...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K9/06A61K47/38A61K47/32A61K47/10A61K45/06A61K31/137A61K31/4174A61K31/496A61P17/00A61P31/10
CPCA61K9/7015A61K9/06A61K47/38A61K47/32A61K47/10A61K45/06A61K31/137A61K31/4174A61K31/496A61P17/00A61P31/10
Inventor 张静林华庆奥姆·桑巴吉·谢尔克吴涛
Owner BRIGHT FUTURE PHARMA LAB LTD (CN)
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