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Transdermally absorbed Cang'ai oil transfersome gel and preparation method thereof

A technology of transfer body and Cang wormwood, applied in the field of medicine, can solve the problems of low drug load and slow drug absorption rate, and achieve the effects of good biocompatibility, skin irritation, and increase of cumulative penetration.

Inactive Publication Date: 2020-12-04
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drug loading of the Acacia oil delivery patch is relatively low, and the drug absorption rate is relatively slow after transdermal administration. Therefore, it is necessary to find a better transdermal preparation for promoting the transdermal absorption of Acacia oil.

Method used

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  • Transdermally absorbed Cang'ai oil transfersome gel and preparation method thereof
  • Transdermally absorbed Cang'ai oil transfersome gel and preparation method thereof
  • Transdermally absorbed Cang'ai oil transfersome gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Preparation of Artemisia argyi oil transfer body:

[0046] A. Prepare materials according to the following mass parts:

[0047]

[0048]

[0049] A1. Take 8.3 parts of soybean lecithin and 1.4 parts of cholesterol in a 10mL centrifuge tube, add 166.7 parts of petroleum ether, and ultrasonically dissolve it in a 250W ultrasonic cleaning machine for 10 minutes to obtain a uniform petroleum ether solution;

[0050] A2, the petroleum ether solution is moved to the 50mL pear-shaped bottle, and the petroleum ether is evaporated under reduced pressure by rotation, that is, a uniform lipid film is formed on the wall of the pear-shaped bottle;

[0051] A3. Take 0.5 parts of sodium cholate and 16.7 parts of propylene glycol and add them to 123.1 parts of deionized water, and perform ultrasonic treatment in a 250W ultrasonic cleaner for 10 minutes to dissolve sodium cholate and propylene glycol in water to obtain an aqueous membrane softener solution;

[0052] A4, get 16.7 ...

Embodiment 2

[0056] Preparation of Artemisia argyi Oil Transfersome

[0057] B. Prepare materials according to the following mass parts:

[0058]

[0059]

[0060] B1. Take 10.0 parts of soybean lecithin and 1.7 parts of cholesterol in a 10 mL centrifuge tube, add 166.7 parts of petroleum ether, and ultrasonically dissolve it in a 250W ultrasonic cleaning machine for 10 minutes to obtain a uniform petroleum ether solution;

[0061] B2, the sherwood oil solution is moved to the 50mL pear-shaped bottle, and the sherwood oil is evaporated by rotating under reduced pressure, and a film is formed on the wall of the pear-shaped bottle;

[0062] B3. Take 0.67 parts of sodium cholate and 25.0 parts of propylene glycol and add them to 103.6 parts of deionized water, and perform ultrasonic treatment for 10 minutes in a 250W ultrasonic cleaning machine to dissolve sodium cholate and propylene glycol in water to obtain a uniform membrane softener aqueous solution;

[0063] B4, get 25.0 parts of...

Embodiment 3

[0067] Preparation of Artemisia argyi Oil Transfersome

[0068] C. Prepare materials according to the following mass parts:

[0069]

[0070] C1. Take 11.7 parts of soybean lecithin and 1.9 parts of cholesterol in a 10mL centrifuge tube, add 166.7 parts of petroleum ether, and ultrasonically dissolve it in a 250W ultrasonic cleaning machine for 10 minutes to obtain a uniform petroleum ether solution;

[0071] C2, the sherwood oil solution is moved in the pear-shaped bottle, and the sherwood oil is evaporated under rotary decompression, and a film is formed on the pear-shaped bottle wall;

[0072] C3. Add 0.8 parts of sodium cholate and 33.3 parts of propylene glycol into 85.7 parts of deionized water, and ultrasonically dissolve them in a 250W ultrasonic cleaner for 10 minutes to dissolve sodium cholate and propylene glycol in water to obtain a uniform membrane softener aqueous solution;

[0073] C4, get 33.3 parts of wormwood oil and join in the membrane softener aqueous ...

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Abstract

The invention provides transdermally absorbed Cang'ai oil (compounded essence oil extracted from seven kinds of traditional Chinese medicines described as in the specification) transfersome gel and apreparation method thereof. The transdermally absorbed Cang'ai oil transfersome gel is prepared from the following components in parts by mass of 15-150 parts of a Cang'ai oil transfersome, 5-15 partsof a gel matrix, 30-150 parts of normal saline, 10-50 parts of a humectant and 3-10 parts of a pH value regulator. The Cang'ai oil transfersome gel prepared by the invention can significantly increase the in-vitro cumulative permeation amount of a drug after transdermal administration, improve the transdermal absorption of C max, AUC0-t and AUC0-infinity in the body of a rat, improve the bioavailability of the drug, prolong the action time of the drug, can be locally smeared or applied during use, avoids the problems of short drug action time, poor stability, poor patient compliance, easy leakage of the Cang'ai oil transfersome, easy loss of transdermal administration liquid, low drug loading amount of the Cangai oil carrier, uneven drug release and the like, covers the bad smell of the drug, and has no irritation to the skin.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a percutaneously absorbed mugwort oil transfer body gel and a preparation method thereof. Background technique [0002] Artemisia argyi oil is a compound essential oil extracted from seven medicinal materials such as atractylodes atractylodes, Artemisia argyi, Huoxiang, Peilan, clove, and Zanthoxylum bungeanum. Its main components are eugenol (38.42%), 1,8-cineole (12.13%), β-Caryophyllene (9.79%), etc., are currently clinically administered through nasal drops and sprays for the treatment of upper respiratory tract infections in children. Preliminary studies have shown that it has good antibacterial activity, and has a strong killing effect on Staphylococcus aureus, Escherichia coli, beta-hemolytic streptococcus, and Candida albicans, and has a certain inhibitory effect on Pseudomonas aeruginosa. In a recent study, Mochou found that Artemisia argyi oil can reduce the content ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/758A61K9/06A61K9/70A61P11/00A61P31/04A61P31/10A61P29/00A61P37/04A61P25/24
CPCA61K9/0014A61K9/06A61K9/703A61K36/28A61K36/282A61K36/284A61K36/532A61K36/61A61K36/758A61P11/00A61P25/24A61P29/00A61P31/04A61P31/10A61P37/04A61K2300/00
Inventor 马云淑张昆熊磊李亶烨程欣高家菊刘云宽
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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