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Ultrasonic circulating focusing emission transdermal drug delivery device and control method

A technology of transdermal drug delivery and ultrasonic circulation, applied in the field of medical devices, can solve problems such as strong penetration and inability to effectively push drug particles

Active Publication Date: 2020-12-04
NANJING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] These devices can carry out targeted drug delivery and improve the efficiency of ultrasonic transdermal drug delivery to a certain extent, but there are still some shortcomings: the focus area in the ultrasonic field is where the intensity of the sound wave is the highest and the vibration direction of the particle is vertical to the depth direction. The drug particles have the strongest penetration effect deep into the human body, and these devices only have one focus position, which cannot effectively push the drug particles for a long distance in the depth direction

Method used

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  • Ultrasonic circulating focusing emission transdermal drug delivery device and control method
  • Ultrasonic circulating focusing emission transdermal drug delivery device and control method
  • Ultrasonic circulating focusing emission transdermal drug delivery device and control method

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Embodiment Construction

[0032] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0033] Such as figure 1 As shown, the ultrasound transducer array is in close contact with the drug pool on the skin surface. The transducer array is in a linear form, with a total of N array elements. The width of each array element is L, and the interval between adjacent array elements is dL. The ultrasonic emission is controlled by the ultrasonic host, and the focus is achieved by driving the signal phase differently during emission. Move, move the emission focus from shallow to deep, form a continuous downward driving force, and push the drug particles to reach the target area.

[0034] Such as figure 2 As shown, firstly, the operator sets the drug emission parameters according to the medical image observation of the lesion, and then the ultrasound host automatically calculates the number and position of the focal points, the number an...

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Abstract

The invention discloses an ultrasonic circulating focusing emission transdermal drug delivery device and a control method. The device comprises an ultrasonic host and a transducer array, wherein the ultrasonic host controls the transducer array to emit ultrasonic waves, and the focusing mode of the transducer array is realized through phase modulation. The control method comprises the steps of automatically performing circulating focusing emission and automatically moving drug delivery emission sound beams one by one. By adopting the circulating focusing emission, a continuous stronger sound field in the vertical depth direction can be formed on a transdermal drug delivery passage, so that continuous driving force is provided for drug particles, the drug particles can favorably reach a deeper subcutaneous focus, and the drug permeation can be better performed.

Description

technical field [0001] The invention relates to a transdermal drug delivery device and a control method for ultrasonic circular focused emission, belonging to the technical field of medical devices. Background technique [0002] Ultrasound is a mechanical vibration with a vibration frequency exceeding 20,000 Hz, which is generally generated by an ultrasonic transducer and can propagate in solids, liquids, and gases. Ultrasound with a certain power can be used in medical treatment, transdermal drug delivery, physical therapy and beauty treatment, etc. In order to achieve more convenient control and more powerful functions, several ultrasonic transducers are generally combined into an array, and different ultrasonic waves are emitted under the control of the control circuit to meet different business needs. [0003] Transdermal drug delivery refers to a treatment method that uses physical or chemical methods to make the drug penetrate the skin and enter the circulatory system...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61N7/02
CPCA61M37/0092A61N7/02A61M2037/0007A61N2007/0004A61N2007/0078
Inventor 章东薛洪惠屠娟宋人杰郭霞生
Owner NANJING UNIV
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