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Coating composition for applying inkjet printing thereto to form marked preparation, preparation marked with aqueous ink, and method for producing marked preparation

A technology of composition and water-based ink, which is applied in the direction of copying/marking methods, making medicines into special physical or taking forms, printing, etc., can solve the problems of dye ink fading, achieve good ink affinity, shorten Effect of drying time, excellent gloss

Pending Publication Date: 2020-12-08
SHIN ETSU CHEM IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, dye ink has the disadvantage of fading due to light

Method used

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  • Coating composition for applying inkjet printing thereto to form marked preparation, preparation marked with aqueous ink, and method for producing marked preparation

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0050] Next, a method for preparing a preparation marked with an aqueous ink will be described, the method comprising: a coating step of coating an object with the above-mentioned coating composition to form a coating layer; and a printing step of coating the coating layer with an aqueous ink Inkjet printing was carried out on the ink to obtain the formulation marked with aqueous ink.

[0051] The coating step in the preparation method of the aqueous inkjet-printed formulation will be described. The object to be coated is preferably a core comprising an active ingredient or a mold pin for forming a capsule. More specifically, the coating step preferably includes coating a core containing an active ingredient with the above-mentioned coating composition, or coating a mold pin for forming a capsule with the above-mentioned coating composition.

[0052] Examples of coating a core containing an active ingredient with the above coating composition will be described.

[0053] The ...

Embodiment 1

[0118] By dispersing 1.5 g of polyvinyl alcohol (the degree of saponification is 88.0 mol%, the viscosity at 20° C. determined in its 4 mass % aqueous solution is 5.30 mPa·s and is a product of Japan VAM & PVA Co., Ltd.) in 270 g of polyvinyl alcohol Pure water was stirred at 25° C. with a stirrer (laboratory stirrer LT-400D produced by Yamato Scientific Co., Ltd.) at 560 rpm for 2 minutes, and then polyethylene was dissolved in pure water and stirred at 60° C. at 560 rpm for 6 Minutes, an aqueous solution of polyvinyl alcohol was prepared.

[0119] While stirring the polyvinyl alcohol aqueous solution at 560 rpm at 80° C. with a stirrer (laboratory stirrer LT-400D produced by Yamato Scientific Co., Ltd.), 28.5 g of HPMC (methoxy group content: 28.8% by mass, The hydroxypropoxy group content is 8.8% by mass, and the viscosity at 20°C determined in its 2% by mass aqueous solution is 5.91 mPa·s) is added thereto, stirred at 560 rpm at 80°C for 3 minutes to disperse therein, and ...

Embodiment 2 to 3 and comparative example 1 to 3

[0183] A coating composition was prepared for inkjet printing thereon to form a marked formulation, and the uncoated tablet was coated with this composition, except that the composition used for the coating formulation was changed to that described in Table 1. The coated tablets were evaluated in the same manner as in Example 1 in terms of affinity, ink bleeding and gloss except those of . The results are shown in Table 1 and Table 2.

[0184]

[0185] In each of Examples 1, 2 and 3, wherein the coating layer contains water-soluble cellulose ether and PVA in a predetermined mass ratio, the coating layer has good ink affinity, ink bleeding inhibition and good glossiness .

[0186] On the other hand, in Comparative Example 1, in which the coating layer contained water-soluble cellulose ether and PVA whose mass ratio was outside the specified range, ink affinity and gloss at the end of the measurement were good, but initial ink affinity was observed Poor compatibility and co...

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Abstract

There are provided a coating composition for applying inkjet printing thereto to form a marked preparation, the composition providing good ink affinity, suppression of ink bleed, and excellent gloss;and others. More specifically, there are provided a coating composition for applying inkjet printing thereto to form a marked preparation, the composition including a water-soluble cellulose ether having a viscosity at 20 DEG C of from 2 to 50.0 mPa.s, as determined in 2% by mass aqueous solution, polyvinyl alcohol, and a solvent, wherein a mass ratio of the water-soluble cellulose ether to the polyvinyl alcohol is from 99.0:1.0 to 55.0:45.0; a method for producing a preparation marked with aqueous ink, including a coating step of coating an object with the composition to form a coating layer,and a printing step of inkjet-printing on the coating layer with aqueous ink to obtain a preparation marked with aqueous ink; and others.

Description

technical field [0001] The present invention relates to a coating composition for inkjet printing thereon to form a marked formulation, a formulation marked with an aqueous ink, and a method of preparing a formulation marked with an aqueous ink. Background technique [0002] In the medical field, it is desirable to develop dosage forms with excellent visual distinction to improve medication compliance while preventing dispensing errors, medication errors, and administration of counterfeit drugs. Typical dosage forms for enhanced differentiation include, for example, engraved tablets. However, due to the filling of the engraved portion during film coating on the engraved tablet, there are still problems of abrasion of the engraved portion and difficulty in distinguishing the engraved tablet. [0003] To avoid these problems, it is known to print barcodes, product names or product codes on medical preparations to improve identification. Known examples of such printing includ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09D11/30A61K9/48A61K9/28
CPCC09D11/30A61K9/2866A61K9/284A61K9/2893A61K9/4816C09D101/26C09D11/322A61K9/4883A61K9/2072C09D11/08B41M5/0088A61J3/007A23P20/00B41M5/0017C09D11/033C09D11/106C09D11/14C09D11/54B41J3/4073C09D5/1668C09D101/02
Inventor 小林绚星野贵史
Owner SHIN ETSU CHEM IND CO LTD
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