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Method for evaluating quality of cold-treating and cough-relieving granules by combining multi-index components with fingerprint spectrum

A technology for fingerprinting, cold and cough, which is applied in the field of quality analysis of traditional Chinese medicine, can solve problems such as the difficulty in comprehensively and effectively evaluating the quality of cold and cough granules, and achieve the effects of easy promotion, strong practicability and high accuracy

Active Publication Date: 2020-12-08
淄博市食品药品检验研究院
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Problems solved by technology

However, the inventor found that the original standard was recorded in the 2015 edition of the "Chinese Pharmacopoeia", and only one component of baicalin was determined, so it was difficult to comprehensively and effectively evaluate the quality of Ganmaozhike Granules

Method used

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  • Method for evaluating quality of cold-treating and cough-relieving granules by combining multi-index components with fingerprint spectrum
  • Method for evaluating quality of cold-treating and cough-relieving granules by combining multi-index components with fingerprint spectrum
  • Method for evaluating quality of cold-treating and cough-relieving granules by combining multi-index components with fingerprint spectrum

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Experimental program
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Effect test

Embodiment 1

[0042] 1 Instruments and reagents

[0043] Agilent 1260 series high performance liquid chromatography (DAD detector), Agilent ZORBAX XDB-C 18 Column (250mm×4.6mm, 5μm), analytical balance (METTLER AE 240), KS-300E ultrasonic cleaner (Ningbo Kesheng Instrument Factory, 300W, 40HZ).

[0044] Neochlorogenic acid (E0420010, 100.0%), chlorogenic acid (110753-201817, 96.8%), puerarin (110752-201615, 95.4%), 3′-methoxypuerarin (T3530010, 100.0%), daidzein (111610-201607, 93.3%), baicalin (110715-201016), forsythin (110821-201112), wogonin, baicalein (111595-200604) and wogonin (111514-200403), of which neoorthoic acid , 3′-Methoxypuerarin was purchased from ANPEL, and the rest of the reference substances were purchased from China National Institutes for Food and Drug Control. Acetonitrile is chromatographically pure (Merk), water is ultrapure water (self-made), methanol (Merk), and phosphoric acid (Yantai Far East Fine Chemical Co., Ltd.) are analytically pure. The 13 batches of sam...

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Abstract

The invention belongs to the field of traditional Chinese medicine quality evaluation, and relates to a method for evaluating the quality of granules for treating cold and relieving cough by combiningmulti-index components with fingerprints, which adopts reversed-phase high-performance liquid chromatography and gradient elution by using acetonitrile and 0.1% phosphoric acid aqueous solution to simultaneously analyze and determine 10 components of 13 batches of granules for treating cold and relieving cough, and researches the fingerprints of the 10 components. Results show that 10 components(neochlorogenic acid, chlorogenic acid, puerarin, 3 '-methoxypuerarin, daidzein, baicalin, forsythin, wogonoside, baicalein and wogonin) are well separated, the sampling recovery rate is 98.98%-100.6%, and the similarity of 13 batches of samples at 250 nm is lower than 0.90 or above. Principal component analysis and thermogram analysis results show that the established content determination and characteristic spectrum analysis combined method proves that the cold-relieving and cough-relieving granules of different manufacturers are obviously different.

Description

technical field [0001] The invention belongs to the field of quality analysis of traditional Chinese medicines, and in particular relates to the quality evaluation of Ganmaozhike granules in combination with multi-index components and fingerprints. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Ganmao Zhike Granules are traditional Chinese medicine preparations, which are composed of Bupleurum chinensis, mountain silver flower, kudzu root, artemisia annua, forsythia, scutellaria baicalensis, bellflower, bitter almond, and menthol. For common cold and fever, headache and stuffy nose, cold and cough, sore throat, lassitude of limbs, influenza. The nine kinds of medicinal ...

Claims

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Application Information

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IPC IPC(8): G01N30/89G01N30/02G01N30/06G01N30/14G01N30/34G01N30/86
CPCG01N30/89G01N30/02G01N30/06G01N30/14G01N30/34G01N30/8682G01N30/8686G01N30/8679G01N2030/062
Inventor 冯巧巧刘宏明张延光张叶
Owner 淄博市食品药品检验研究院
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