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Method for blocking microfluidic fluid channel by hot pressing

A fluid channel and microfluidic control technology, which is applied in the field of hot pressing equipment, can solve the problems of complete and permanent closure of difficult channels, complex instruments, and influence, and achieve the effect of easy operation and simple control of equipment

Inactive Publication Date: 2020-12-18
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] These methods usually require more precise control or relatively complex components, which is not conducive to widespread use in many application scenarios outside the laboratory
For example, the direct pressing method is difficult to completely and permanently seal the channel, which makes the micro-reaction unit not really isolated from the outside world, and is easily affected by the outside world or has an impact on the outside world.
However, the slide chip method and the microvalve method have high requirements on the processing accuracy of the components, and the laser welding method requires more complicated instruments, which is not conducive to many scenarios outside the laboratory.

Method used

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  • Method for blocking microfluidic fluid channel by hot pressing
  • Method for blocking microfluidic fluid channel by hot pressing
  • Method for blocking microfluidic fluid channel by hot pressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A set of small hot-pressing devices of the present invention realizes the sealing of the flow channel in the microfluidic chip. Whether the fluid in the channel is gas or liquid, it can be blocked by the method of the present invention.

[0048] like figure 1As shown, the small thermocompression device can move relative to the microfluidic chip, and the moving direction can be perpendicular to the surface of the microfluidic chip or non-vertical. The heatable surface of the heat press device is in contact with at least one surface of the flow channel of the microfluidic chip, and the polymer material forming the flow channel is brought into a glassy state or melted by heating. The small thermocompression device applies a pressure to the surface of the microfluidic chip, causing glassy or molten polymer material to be squeezed into the flow channel, completely filling it. Subsequently, the small thermocompression device was separated from the microfluidic chip. The gl...

Embodiment 2

[0059] The structure consists of a microfluidic chip, double-sided adhesive tape, thermoplastic polyurethane film and Teflon heat-resistant tape. The specific structure from bottom to top is: microfluidic chip, double-sided tape, thermoplastic polyurethane and Teflon heat-resistant tape. Among them, thermoplastic polyurethane can be squeezed into the fluid channel after melting to block the fluid channel, and Teflon heat-resistant tape is used to prevent thermoplastic polyurethane from adhering to the hot pressing device during the hot pressing process.

[0060] The microfluidic chip with the flow channel is processed by 3D printing heat-resistant resin. The launder has a width of 1 mm, a depth of 1 mm, and a length of 20 mm.

[0061] The design of the microfluidic chip is drawn by Solidworks software, and the microfluidic chip can be made by 3D printing or injection molding. Double-sided adhesive tape, thermoplastic polyurethane film and Teflon heat-resistant tape are all p...

Embodiment 3

[0066] like Figure 2(a)-Figure 2(b) , Figure 3(a)-Figure 3(b) As shown, the microfluidic chip with flow channel is processed by 3D printing heat-resistant resin. The width of the launder is 1mm, the depth is 1mm, and the length is 20mm

[0067] Clean the microfluidic chip and thermoplastic polyurethane film with ethanol to remove oil and impurities attached to the surface. The polyurethane film is bonded to the surface of the chip with the microfluidic flow channel by heat-resistant superglue.

[0068] Figure 7 and Figure 8 As shown, the hot pressing device 4 is fixed on a sliding rod stepping motor 1 through the fixed arm 2, and the motor 1 can control the hot pressing device 4 to move up and down through the lifting arm 3, and the moving speed is 1 mm per second. The assembled microfluidic chip 6 is placed under the heating module, and the fluid channel to be blocked is placed in the vertical direction of the heating surface 5. In the initial state, the heating surfa...

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Abstract

The invention discloses a method for blocking a microfluidic fluid channel by hot pressing, and relates to the field of hot pressing equipment. The method for blocking the microfluidic fluid channel by hot pressing is characterized by comprising the following steps of A, assembling a microfluidic chip; B, placing the assembled microfluidic chip below a hot pressing device; C, heating the hot-pressing device; D, moving the microfluidic chip to the hot-pressing device and keeping pressure contact; and E, separating the hot-pressing device from the microfluidic chip. The method for sealing the microfluidic flow channel provided by the invention is simple, easy to operate and free of complex control equipment, and the microfluidic flow channel can be permanently and completely sealed.

Description

technical field [0001] The invention relates to the field of hot pressing equipment, in particular to a method for hot pressing to block microfluidic fluid channels. Background technique [0002] Microfluidics is a technology that controls micro-volume fluids to realize various micro-scale physical, chemical and biological processes. Microfluidics can integrate many reactions performed in laboratories onto microfluidic chips, so it is called a laboratory on a chip in many scenarios. The volume of fluid being treated may also be larger or smaller in some specific cases. Microfluidic chips usually have one or more fluid channels. Under the action of different action mechanisms such as external pressure, density, gravity, surface tension, capillary action, and mechanical action, the fluid can be transported in the channel of the microfluidic chip. [0003] Various biochemical reactions with different mechanisms can be realized on the microfluidic chip, and analysis and resea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C65/02
CPCB29C65/02B29C66/02B29C66/47
Inventor 吕蔚元沈峰
Owner SHANGHAI JIAO TONG UNIV