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Application of atf4 inhibitor in the preparation of medicine for preventing or treating ankylosing spondylitis

Ankylosing spondylitis, ATF4 technology, applied in the field of medicine and biology, can solve problems such as joint ankylosis, limited joint and spine movement, inflammatory pain at the starting and ending points of tendon, etc., to prevent spinal deformity, inhibit angiogenesis and pathological Osteogenesis and the effect of preventing ankylosis

Active Publication Date: 2022-07-29
THE EIGHTH AFFILIATED HOSPITAL SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Ankylosing spondylitis is difficult to diagnose early, and the etiology has not been clarified so far. Current treatment methods can only relieve inflammation. As the disease progresses, patients will experience inflammatory pain at the starting and ending points of the tendon and low back pain; joint and spine mobility is limited, and severe cases may develop Ankylosis and pathological osteoblastic fusion deformity of the spine

Method used

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  • Application of atf4 inhibitor in the preparation of medicine for preventing or treating ankylosing spondylitis
  • Application of atf4 inhibitor in the preparation of medicine for preventing or treating ankylosing spondylitis
  • Application of atf4 inhibitor in the preparation of medicine for preventing or treating ankylosing spondylitis

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Experimental program
Comparison scheme
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Embodiment 1

[0020] (1) Construction of AS mouse animal model

[0021] 24-week-old female BALB / c mice were selected and intraperitoneally injected with Proteoglycan (once in each of the 0, 3, and 6 weeks, 3 times in total, 100ug each time) to obtain an AS mouse model .

[0022] (2) group administration

[0023] The AS mice obtained in step (1) were randomly divided into three groups, including control group, TNF-α antagonist group and ATF4 inhibitor (KIRA-7, imidazopyrazine compound) group, starting from the 10th week, The three groups were given normal saline, TNF-a antagonist and ATF4 inhibitor (KIRA-7, C 27 H 23 FN 6 O, imidazopyrazine compound) each 5 mg / kg tail vein injection, once every 4 weeks, to the 30th week, a total of 6 injections.

[0024] (3) Detection of angiogenesis and pathological osteogenesis in mice

[0025] From the 14th week, the mice in the three groups were sacrificed by overdose anesthesia, once every 4 weeks, up to the 34th week, a total of 6 times.

[0026...

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Abstract

The invention relates to the field of medicine and biology, in particular to the application of an ATF4 inhibitor in the preparation of a medicament for preventing or treating ankylosing spondylitis. At present, AS treatment has not been able to solve the problem of pathological osteogenic fusion of joints and spine of patients. In order to prevent the occurrence of joint ankylosis and spinal deformity, the present invention finds a new AS treatment target; The invention can effectively inhibit the angiogenesis and pathological osteogenesis of AS lesions, and break through the bottleneck of AS treatment.

Description

technical field [0001] The invention relates to the field of medicine and biology, in particular to the application of an ATF4 inhibitor in the preparation of a medicament for preventing or treating ankylosing spondylitis. Background technique [0002] Ankylosing spondylitis (AS) is a disease characterized by inflammation of the sacroiliac joints and spinal attachment points. The cause is not yet clear, and there is no cure. The treatment of AS is mainly to control inflammation, reduce or relieve symptoms, maintain normal posture and optimal functional position, and prevent deformity. Treatment is divided into drug treatment, non-drug treatment and surgical treatment. Non-drug therapy includes maintaining normal posture, such as chest and abdomen when sitting and standing; moderate physical exercise; maintaining an optimistic mood, quitting smoking, etc. Non-steroidal anti-inflammatory drugs (NSAIDs) are the first choice for drug treatment, and other drug treatments inclu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4985A61P19/08A61P19/02A61P29/00
CPCA61K31/4985A61K9/0019A61K9/0043A61P19/08A61P19/02A61P29/00
Inventor 沈慧勇马梦君杨文李鸿宇吴燕峰王鹏米汝佳卢艺萱
Owner THE EIGHTH AFFILIATED HOSPITAL SUN YAT SEN UNIV