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Skin lightening agent

A whitening agent and whitening technology, applied in the field of whitening agents, can solve problems such as undesired and inability to fully meet needs, and achieve excellent whitening effects

Active Publication Date: 2020-12-25
POLA CHEM INDS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, some existing whitening agents have been confirmed to have a certain whitening effect, but they may not be sufficient to meet the needs, or other undesirable effects (side effects) may occur at the concentration at which the whitening effect is exhibited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0075] Hereinafter, the present invention will be described in more detail with reference to specific experimental examples, but the present invention is not limited to the following aspects.

[0076]

[0077] The cosmetics described in Table 1 (Examples 1 to 9, Comparative Examples, and Reference Examples) were prepared by conventional methods, respectively.

[0078] For each of the prepared cosmetics, the whitening effect (improvement effect of pigmentation) was evaluated by the following method. That is, a total of eight test sites of 0.5 cm x 0.5 cm were set on the inner sides of the left and right upper arms of 10 voluntary panelists. Ultraviolet radiation with a minimum erythema dose (1 MED) was irradiated to the site where it was installed once a day for 3 consecutive days. From the end of ultraviolet irradiation on the first day of the test (after the end of the first irradiation), any one of Examples 1 to 9 and Reference Example was applied to the comparative examp...

manufacture example 1

[0086] A lotion as an external preparation for skin of the present invention was prepared using the formulation shown in Table 3. That is, the components of A are heated at room temperature, and the components of B are heated and mixed at 60°C, and B is slowly added to A under stirring, and the lotion is obtained by stirring and cooling.

[0087] It was confirmed that this lotion has a whitening effect when applied to the skin.

[0088] [table 3]

[0089]

[0090]

manufacture example 2

[0092] A lotion as an external preparation for skin of the present invention was prepared using the formulation shown in Table 4. That is, component A is heated at normal temperature and component B is heated and mixed at 60°C, and B is slowly added to A under stirring, and the lotion is obtained by stirring and cooling.

[0093] It was confirmed that this lotion has a whitening effect when applied to the skin.

[0094] [Table 4]

[0095]

[0096]

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PUM

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Abstract

The present invention addresses the problem of providing a skin lightening agent that has an excellent skin lightening effect. An active ingredient of the skin lightening agent is a compound represented by general formula (1) or acid-addition salts thereof. (In the formula, X represents a C1-C2 alkylene group in which a hydrogen atom may be substituted by a methyl group; Y represents COOR1 or CH2OR2; R1 represents a hydrogen atom or a C1-C6 alkyl group which may be branched; and R2 represents a hydrogen atom or a C1-C6 acyl group which may be branched.).

Description

technical field [0001] The present invention relates to a whitening agent having an excellent whitening effect. Background technique [0002] It is known that skin symptoms caused by pigmentation such as freckles, freckles, liver spots, and skin melanism caused by drugs are due to the hyperproduction of melanin in pigment cells (melanocytes) in addition to sunburn caused by ultraviolet exposure Afterwards, the melanin produced is deposited on the skin due to abnormal turnover (turnover) and the like. [0003] Skin symptoms related to such pigmentation can be easily recognized from the appearance, so it has a large influence on the image of the face. Therefore, the prevention and improvement of skin pigmentation are highly interested in the prevention and improvement of skin pigmentation mainly by people who desire beautiful skin, and the demand for whitening agents and cosmetics for whitening has also increased in recent years. [0004] Conventionally, ascorbic acid, hydro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/44A61K8/41A61Q19/02
CPCA61Q19/02A61K8/41A61K8/44A61K2800/434
Inventor 佐佐祥子森靖仁齐藤优子
Owner POLA CHEM INDS